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Muscarinic modulation of the trigemino-reticular pathway in lampreys. | LitMetric

Muscarinic modulation of the trigemino-reticular pathway in lampreys.

J Neurophysiol

Dépt. de Kinanthropologie, C.P. 8888, Université du Québec à Montréal, Succ. Centre-Ville, Montréal, Québec H3C 3P8, Canada.

Published: August 2004

AI Article Synopsis

  • - The study investigates how cholinergic inputs influence reticulospinal neurons in lampreys, which are crucial for controlling locomotion by integrating sensory information.
  • - Researchers discovered that muscarinic acetylcholine receptors modulate trigeminal sensory inputs to reticulospinal neurons, leading to decreased sensory responses when activated.
  • - Muscarinic antagonists, which block these receptors, increase trigeminal responses, suggesting that this modulation is normally active and important for how sensory signals are processed in the context of locomotion.

Article Abstract

In lampreys, reticulospinal neurons integrate sensory inputs to adapt their control onto the spinal locomotor networks. Whether and how sensory inputs to reticulospinal neurons are modulated remains to be determined. We showed recently that cholinergic inputs onto reticulospinal neurons play a key role in the initiation of locomotion elicited by stimulation of the mesencephalic locomotor region in semi intact lampreys. Here, we examined the possible role of muscarinic acetylcholine receptors in modulating trigeminal inputs to reticulospinal neurons. A local application of muscarinic agonists onto an intracellularly recorded reticulospinal cell depressed the disynaptic responses to trigeminal stimulation. A depression was also observed when muscarinic agonists were pressure ejected over the brain stem region containing second-order neurons relaying trigeminal inputs to reticulospinal neurons. Conversely, muscarinic antagonists increased the trigeminal-evoked responses, suggesting that a muscarinic depression of sensory inputs to RS neurons is exerted tonically. The muscarinic modulation affected predominantly the N-methyl-d-aspartate (NMDA) component of the trigeminal-evoked responses. Moreover, atropine perfusion facilitated the occurrence of sustained depolarizations induced by stimulation of the trigeminal nerve, and it revealed NMDA-induced intrinsic oscillations in reticulospinal neurons. The functional significance of a muscarinic modulation of a sensory transmission to reticulospinal neurons is discussed.

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Source
http://dx.doi.org/10.1152/jn.01025.2003DOI Listing

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