The dosage form of medamine-medapec was found to have a high antiechinococcal activity in experiments on laboratory animals. Its efficacy was shown in treating larval alveolar echinococciasis in mice and cotton rats with different doses and courses as compared with medamine and albendazole. It was ascertained that for its high larvicidal activity, medapec should be given to animals regularly during a day. The daily dose of the drug should be gradually increased. In complying with these conditions, the duration of effective courses of therapy drastically reduces.
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Minerva Urol Nephrol
December 2024
European Association of Urology (EAU), Young Academic Urologists (YAU) Renal Cancer Working Group, Arnhem, the Netherlands.
Background: Bilateral synchronous renal masses (BSRMs) are a rare finding, and the optimal treatment strategy remains undetermined. This study depicts the management of BSRM at eight European high-volume centers.
Methods: This is a retrospective analysis of prospective institutional databases collecting all patients presenting with clinical T1-2 N0 M0 BSRMs between 1993 and 2020 at 8 tertiary referral high-volume centers for renal cancer treatment in Europe.
Transl Lung Cancer Res
December 2024
Department of Physics and Center for Complexity and Biosystems, Università degli Studi di Milano and INFN, Milano, Italy.
Background: Non-small cell lung cancers (NSCLCs) with fusions are effectively treated with tyrosine kinase inhibitors (TKIs). The widespread use of next-generation sequencing (NGS) assays to study the molecular profile of NSCLCs, can identify rare fusion partners of . Therapy decisions are made without considering which fusion partner is present and its potential oncogenic properties.
View Article and Find Full Text PDFNat Commun
January 2025
AI for Science (AI4S)-Preferred Program, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
In chemistry, empirical paradigms prevail, especially within the realm of chromatography, where the selection of separation conditions frequently relies on the chemist's experience. However, the underlying rationale for such experiential knowledge has not been established or analysed. This study explicitly elucidates how chemists use thin-layer chromatography (TLC) to determine column chromatography (CC) conditions, employing statistical analysis and machine learning techniques.
View Article and Find Full Text PDFCancer Lett
January 2025
Moores Cancer Center, University of California San Diego, La Jolla, CA USA; Department of Pharmacology, University of California San Diego, La Jolla, CA USA. Electronic address:
Genetic alterations in Hippo pathway and the consequent activation of YAP/TAZ-TEAD are frequently observed in HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. These include loss-of-function mutation and/or copy number loss of FAT1, and amplification of YAP1 and WWTR1 (encoding TAZ), thus raising the possibility that HNSCC cells may be dependent on YAP/TAZ-TEAD-mediated transcriptional programs. In this regard, the recent development of small molecule TEAD inhibitors (smTEADi) provides an opportunity to therapeutically target Hippo pathway dysregulation in human malignancies.
View Article and Find Full Text PDFContemp Clin Trials
January 2025
Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 135 Dauer Drive, 245 Rosenau Hall, CB # 7461, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, 450 West Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, 170 Rosenau Hall, CB #7400, Chapel Hill, NC 27599, USA; Nutrition Research Institute, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.
Background: Young adults (YAs) are underrepresented in behavioral health and weight loss interventions and express interest in flexible, highly tailored programs. Mobile interventions are a lower-burden, scalable approach to providing behavioral support. Just-in-time-adaptive interventions (JITAI) promise to deliver the "right" support at the "right" time using real-time data from smartphones and sensors.
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