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Evaluation of Chemical Composition and Anti-Staphylococcal Activity of Essential Oils from Leaves of Two Indigenous Plant Species, and .
Plants (Basel)
December 2024
Department of Crop Science and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague, Czech Republic.
Many indigenous plants of the Philippines, including essential oil-bearing species, remain phytochemically and pharmacologically unexplored. In this study, the chemical composition of leaf essential oils (EOs) hydrodistilled from (Lauraceae) and (Piperaceae) was determined using dual-column (HP-5MS/DB-WAX)/dual-detector gas chromatography and mass spectrometry analysis. Caryophyllene oxide (15.
View Article and Find Full Text PDFAnti- Activity of Volatile Phytochemicals and Their Combinations with Conventional Antibiotics Against Methicillin-Susceptible (MSSA) and Methicillin-Resistant (MRSA) Strains.
Antibiotics (Basel)
October 2024
Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
Background: MSSA and MRSA strains are challenging human pathogens that can develop resistance to antibiotics, highlighting the need for alternative antimicrobial agents. Plant metabolites, particularly volatile phytochemicals, may offer promising antimicrobial properties. The aim was to evaluate the antimicrobial and antibiofilm efficacy of various commercial volatile phytochemicals from the terpene and terpenoid groups against reference MSSA and MRSA strains, focusing on synergistic effects in both binary combinations and combinations with antibiotics.
View Article and Find Full Text PDFAnti-staphylococcal activity of a polyphenol-rich citrus extract: synergy with β-lactams and low proficiency to induce resistance.
Front Microbiol
July 2024
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Introduction: Antibiotic resistance represents one of the most significant threats to public health in the 21st century. Polyphenols, natural molecules with antibacterial activity produced by plants, are being considered as alternative antimicrobial strategies to manage infections caused by drug-resistant bacteria. In this study, we investigated the antibacterial activity of a polyphenol mixture extracted from citrus fruits, against both antibiotic-susceptible and resistant strains of and .
View Article and Find Full Text PDFAnti-staphylococcal activity of soilless cultivated cannabis across the whole vegetation cycle under various nutritional treatments in relation to cannabinoid content.
Sci Rep
February 2024
Department of Agroenvironmental Chemistry and Plant Nutrition, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, 165 00, Prague-Suchdol, Czech Republic.
Article Synopsis
- Antibiotic resistance in staphylococcal strains poses serious global health risks, prompting the need for new therapeutic agents.
- Ethanolic extracts from Cannabis sativa demonstrated significant growth inhibition of both antibiotic-resistant and sensitive Staphylococcus aureus, particularly during specific weeks of the plant's growth cycle.
- The study identified THCA as the major cannabinoid in the extracts, with THCVA showing a notable ability to reduce bacterial growth, indicating potential for developing effective anti-staphylococcal treatments.
Abietic Acid as a Novel Agent against Ocular Biofilms: An In Vitro and Preliminary In Vivo Investigation.
Int J Mol Sci
January 2024
Platform for Unique Model Application, Department of Pharmaceutical Microbiology and Parasitology, Medical University of Wroclaw, 50-367 Wroclaw, Poland.
Biofilm-related ocular infections can lead to vision loss and are difficult to treat with antibiotics due to challenges with application and increasing microbial resistance. In turn, the design and testing of new synthetic drugs is a time- and cost-consuming process. Therefore, in this work, for the first time, we assessed the in vitro efficacy of the plant-based abietic acid molecule, both alone and when introduced to a polymeric cellulose carrier, against biofilms formed by , , and in standard laboratory settings as well as in a self-designed setting using the topologically challenging surface of the artificial eye.
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