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http://dx.doi.org/10.1016/j.vaccine.2003.11.042 | DOI Listing |
Alzheimers Dement
December 2024
Massachusetts General Hospital, Boston, MA, USA.
Background: In cognitively unimpaired (CU) older adults, the presence of a subjective cognitive decline (SCD) combined with evidence of abnormal b-amyloid (Ab) is proposed as stage 2 of Alzheimer's disease (AD) by the NIA-AA framework (Jack et al., 2018). However, the associations found between SCD and preclinical AD are inconsistent across studies, highlighting the importance of better understanding which specific SCD features are associated with either Ab or tau burden.
View Article and Find Full Text PDFTijdschr Psychiatr
January 2025
Background: Pharmacotherapy is an effective treatment strategy for psychiatric disorders. Nevertheless, many patients discontinue their medication at some point. Evidence-based practices for patients, clinicians, and policymakers to discontinue psychotropic medication properly are therefore important.
View Article and Find Full Text PDFNeurol Educ
December 2024
From the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.
The Clinical Trials Methodology Course (CTMC), given from 2014 to 2023, was conducted to educate early-career clinical investigators from various backgrounds in neurosciences in the design of clinical trials and to provide mentorship to enhance academic careers and retention plus improve research productivity and the likelihood of successful grant applications. This summary describes the rationale, history, structure, and trainee outcomes of the CTMC. The course used small groups, consisting of 1-2 clinical faculty advisor(s), 1 faculty biostatistician, and 2-4 trainees who met remotely approximately weekly over 12 weeks.
View Article and Find Full Text PDFAlzheimers Dement (N Y)
November 2024
Department of Neurology Biologic Sciences Division, Healthy Aging and Alzheimer's Research Care Center University of Chicago Chicago Illinois USA.
Introduction: Measurements of health-related quality of life (HRQoL) are important for capturing disease impact beyond physical health and relative to other diseases but have rarely been assessed in primary progressive aphasia (PPA).
Methods: HRQoL was characterized overall, by sex and subtype in PPA ( = 118) using the Health Utilities Index-2/3 (HUI2/3). Multiple linear regression assessed associations between HRQoL and language severity.
Alzheimers Dement (N Y)
December 2024
Alzheimer's Association Chicago Illinois USA.
Unlabelled: The newly proposed revised criteria for diagnosis and staging of Alzheimer's disease (AD) by the Alzheimer's Association (AA) Workgroup represent a significant milestone in the field. These criteria offer objective measures for diagnosing and staging biological AD, bridging the gap between research and clinical care. Although implementation feasibility may vary across regions and settings, improving the availability and accuracy of biomarkers, especially plasma biomarkers, is expected to enhance the applicability of these criteria in clinical practice.
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