A waaF mutant of Campylobacter jejuni 81-176 showed decreased invasion of INT407 cells in vitro and increased sensitivity to some antibiotics compared to what was seen with the wild-type strain.
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http://dx.doi.org/10.1128/IAI.72.4.2452-2455.2004 | DOI Listing |
Front Microbiol
November 2024
Division of Environmental Health Sciences, School of Public Health, University of Minnesota, St. Paul, MN, United States.
Antibiotic tolerance enables antibiotic-susceptible bacteria to withstand prolonged exposure to high concentrations of antibiotics. Although antibiotic tolerance presents a major challenge for public health, its underlying molecular mechanisms remain unclear. Previously, we have demonstrated that develops tolerance to clinically important antibiotics, including ciprofloxacin and tetracycline.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, China.
() is a zoonotic foodborne pathogen that is widely distributed worldwide. Its optimal growth environment is microaerophilic conditions (5% O, 10% CO), but it can spread widely in the atmospheric environment. Biofilms are thought to play an important role in this process.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Food Hygiene and Consumer Health Protection, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Campylobacter jejuni is a major cause of food- and water-borne bacterial infections in humans. A key factor helping bacteria to survive adverse environmental conditions is biofilm formation ability. Nonetheless, the molecular basis underlying biofilm formation by C.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
October 2024
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048.
Int J Mol Sci
September 2024
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Infection with is the major cause of human gastroenteritis in the United States and Europe, leading to debilitating autoimmune sequelae in many cases. While considerable progress has been made in detailing the infectious cycle of , a full understanding of the molecular mechanisms responsible for virulence remains to be elucidated. Here, we apply a novel approach by modulating protein expression on the pathogen's ribosomes by inactivating a highly conserved rRNA methyltransferase.
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