Reactive oxygen species and sperm cells.

Reprod Biol Endocrinol

Institute of Human Genetics, Polish Academy of Sciences, Poznan,

Published: March 2004

There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced. The essential steps of lipid peroxidation have been listed as well as antioxidant substances of semen. A variety of detection techniques of lipid peroxidation have been summarized together with the lipid components of sperm membranes that can be subjected to stress. It is unsolved, a threshold for ROS levels that may induce functional sperm ability or may lead to male infertility.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400757PMC
http://dx.doi.org/10.1186/1477-7827-2-12DOI Listing

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