Histamine H2 and cholecystokinin (CCK)-B/gastrin receptors are very important in both acid secretion and growth and differentiation of the gastric mucosa. Generations of mice deficient in each of these receptors have provided information on the structure and function of the gastric mucosa, respectively. To examine the gastric mucosa in further detail, we generated mice deficient in both receptors. This review discusses the roles of histamine H2 and CCK-B/gastrin receptors in gastric mucosa based on data from our double-null mice.
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