The endothelium is now recognized not only as a physical barrier between blood and vascular wall, but also as an important and strategically located organ with multiple endocrine and paracrine functions. By releasing vasoactive substances, the endothelium acts as an inhibitory regulator of vascular contraction, leukocyte adhesion, vascular smooth muscle cell growth, and platelet aggregation. This review intends to demonstrate how much the picture of the biological functions of nitric oxide has changed in cardiovascular physiology, extending beyond its vessel-relaxing activity, as well as to highlight new insights into the factors affecting its bioavailability and regulation in relation with many cardiovascular diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arcmed.2003.09.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dipyridamole Attenuates Experimental Periodontitis by Regulating M1 Macrophage Polarization via PKA/PKG Pathways.
J Periodontal Res
January 2025
Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Aim: Periodontitis is a chronic inflammatory disease initiated by dysbiosis of the local microbial community. As a non-specific phosphodiesterase inhibitor, dipyridamole features anti-oxidant and anti-inflammatory properties. This study aimed to investigate the effects of dipyridamole in an experimental rat model of periodontitis.
View Article and Find Full Text PDFAntioxidant, antiproliferative and anti-inflammatory activities of squirting cucumber (Ecballium elaterium L).
Pak J Pharm Sci
January 2025
Laboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, Hammam-Lif, Tunisia.
Plants constitute a source of natural phytochemical components which are widely known for their potential biological activities. This work concerned a study of the antioxidant, anticancer and anti-inflammatory activities of squirting cucumber (Ecballium elaterium L.) parts (flowers, fruits, leaves and stems) using different solvent extracts (cyclohexane, dichloromethane, ethyl acetate, methanol and water).
View Article and Find Full Text PDFAssessment of a new protocol strategy to control the ectoparasitic infestation in Nile tilapia (Oreochromis niloticus) using efficient natural products.
BMC Vet Res
January 2025
Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
This study aimed to evaluate alternative in vivo treatment trials using natural products for ectoparasitic infestation on Nile tilapia; these two products were not previously used in the treatment of parasitic fish diseases. So, a total of 400 Oreochromis niloticus (O. niloticus) fish measured 10-15 cm in length; 350 from a fish farm in (Kafr Elsheikh and 50 from Nile River (Al Bahr Al Aazam), Egypt.
View Article and Find Full Text PDFEffect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway.
Brain Res Bull
January 2025
School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Geriatric Diseases, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- The study investigated how electroacupuncture (EA) affects irisin secretion and its role in recovering brain function and blood vessel health after a stroke in rats.
- The research showed that EA increased irisin levels significantly after seven days and improved neurobehavioral function while reducing brain damage and enhancing blood flow and vascular growth.
- These beneficial effects of EA were weakened when the gene responsible for irisin production was silenced, suggesting that irisin plays a critical role in EA’s therapeutic effects on brain recovery.
Exploring the mechanisms of Yang Wei Shu granule for the treatment of chronic atrophic gastritis using UPLC-QTOF-MS/MS, network pharmacology, and cell experimentation.
J Ethnopharmacol
January 2025
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012 Anhui, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012 Anhui, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei 230012 Anhui, China; Anhui Engineering Research Center for Quality Improvement and Utilization of Genuine Chinese Medicinal Materials, Hefei 230012 Anhui, China; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012 Anhui, China. Electronic address:
Article Synopsis
- YWSG is an herbal compound derived from ancient Chinese medicine used for treating chronic atrophic gastritis (CAG), which can lead to gastric cancer.
- The study aims to identify the chemical composition of YWSG and understand its mechanisms of action through advanced analytical techniques and network pharmacology.
- Results revealed 150 compounds in YWSG, with several target genes identified as potential therapeutic targets, and experiments indicated that YWSG does not harm certain immune cells while inhibiting nitric oxide production.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!