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Graph theory analysis of a human body metabolic network: A systematic and organ-specific study.
Med Phys
December 2024
Research Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Purposes: Positron emission tomography (PET) imaging is widely used to detect focal lesions or diseases and to study metabolic abnormalities between organs. However, analyzing organ correlations alone does not fully capture the characteristics of the metabolic network. Our work proposes a graph-based analysis method for quantifying the topological properties of the network, both globally and at the nodal level, to detect systemic or single-organ metabolic abnormalities caused by diseases such as lung cancer.
View Article and Find Full Text PDFEndoscopic papillectomy versus surgical ampullectomy for adenomas and early cancers of the papilla: a retrospective Pancreas2000/European Pancreatic Club analysis.
Gut
December 2024
Department of Digestive and HBP Surgery, Groupe Hospitalier Pitié-Salpêtrière, Médecine Sorbonne Université APHP, Paris, France.
Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.
Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.
Pancreatic atrophy is a predictor for exocrine pancreatic dysfunction: Data from a large cohort of patients with chronic pancreatitis.
Pancreatology
December 2024
Department of Clinical Medicine, University of Bergen, Jonas Lies Vei, 5020, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address:
Article Synopsis
- The study investigates pancreatic atrophy in patients with chronic pancreatitis (CP) to establish diagnostic standards and analyze factors affecting the condition.
- Measurements of pancreatic size and associated variables like calcifications were collected from a cohort of 539 CP patients to determine cutoffs for identifying atrophy and its link to exocrine pancreatic dysfunction (EPD).
- Results show that specific pancreatic size measurements are linked to EPD, with male sex, older age, and longer CP duration being significant risk factors for pancreatic atrophy.
Clinical manifestations of chronic pancreatitis in English cocker spaniels.
J Vet Intern Med
July 2024
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Background: Chronic pancreatitis (CP) is common in English cocker spaniels (ECS). It is histologically similar to IgG4-related disease (IgG4-RD) in humans and is characterized by duct destruction, interlobular fibrosis, and dense periductular and perivenous lymphocytic aggregates. However, the clinical manifestations of CP in ECS have not been previously described.
View Article and Find Full Text PDFManagement of malignant Gastric Outlet Obstruction (mGOO) due to pancreatic cancer in the era of EUS-Gastrojejunostomy: an international practice survey and case vignette study by Pancreas 2000 from the European Pancreatic Club.
Surg Endosc
June 2024
Division of Pancreato-Biliary Endoscopy and Endosonography, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.
Background: Malignant Gastric Outlet Obstruction (mGOO) has been standardly treated by surgical Gastrojejunostomy (S-GJ) or Endoscopic Stenting (ES). Recently, EUS-Gastrojejunostomy (EUS-GJ) has emerged as an alternative, despite its worldwide diffusion is heterogeneous. The aim of this survey was to assess clinical decision-making around mGOO and to explore current opinions regarding EUS-GJ.
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