AI Article Synopsis
- A new method for measuring diltiazem in bulk and dosage forms is introduced, which is easy to replicate.
- The method relies on creating a hydroxamic acid that reacts with iron (III) to produce a complex that can be measured at a wavelength of 525 nm.
- For dosage forms, the process includes using thin-layer chromatography to separate the diltiazem before conducting a colorimetric analysis.
Article Abstract
A simple and reproducible method for determination of diltiazem in bulk and in dosage forms is presented. The method is based on formation of hydroxamic acid, which reacts with iron (III), forming a complex with a maximum absorption at 525 nm. Assay procedure for diltiazem dosage form requires thin-layer chromatographic separation prior to colorimetric analysis.
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