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North American clinical practice guidelines for the medical management of hidradenitis suppurativa in special patient populations.
J Am Acad Dermatol
December 2024
Department of Dermatology, University of California, San Francisco, California.
Background: Hidradenitis suppurativa (HS) affects different patient populations that require unique considerations in their management. However, no HS guidelines for these populations exist.
Objective: To provide evidence-based consensus recommendations for patients with HS in 7 special patient populations: (i) pregnancy, (ii) breastfeeding, (iii) pediatrics, (iv) malignancy, (v) tuberculosis infection, (vi) hepatitis B or C infection, and (vii) HIV disease.
Early Days in the Hunt Laboratory at UVA, 1969 to 1980.
Mol Cell Proteomics
December 2024
Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Arriving at the University of Virginia in the autumn of 1969, Donald Hunt began his 50+ year career in academics with the study of organometallic chemistry, on which he had done his PhD thesis work, and mass spectrometry, to which he was introduced while a postdoc in Klaus Biemann's laboratory at the Massachusetts Institute of Technology. In the 1970s, Hunt's lab pioneered the use of negative chemical ionization (CI) to enhance sensitivity for studying organic molecules, developed a system for simultaneously obtaining positive and negative CI spectra to augment structure elucidation, and built a prototype triple quadrupole instrument so effective at collisional dissociation that its commercial counterpart became the analytical instrument of choice for mixture analysis for the next decade and beyond. Foreseeing that the future lay in the analysis of biological molecules, by the end of the decade Hunt shifted his focus to peptides.
View Article and Find Full Text PDFProfessor Zbigniew J. Witczak: A Tribute.
Carbohydr Res
December 2023
Department of Pharmaceutical Sciences, Wilkes University, Wilkes-Barre, PA, 18766, United States; Chemventive, LLC Chadds Ford, PA, 19317, United States. Electronic address:
Revealing the concealed: A tribute to Donald L. Morton, MD.
Clin Exp Metastasis
August 2024
Department of Surgery, Henry Ford Health, 2799 W Grand Boulevard, Detroit, MI, 48202, USA.
Donald L. Morton, MD, epitomized one of America's dream scenarios: a person evolving from the humblest of origins to become an international celebrity in his profession, leading the world in the discipline of surgical oncology. His pioneering accomplishments in various roles have been well documented.
View Article and Find Full Text PDFHINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham.
Front Mol Biosci
June 2023
Department of Food and Drug, University of Parma and Institute of Biophysics, Parma, Italy.
A long-lasting goal of computational biochemists, medicinal chemists, and structural biologists has been the development of tools capable of deciphering the molecule-molecule interaction code that produces a rich variety of complex biomolecular assemblies comprised of the many different simple and biological molecules of life: water, small metabolites, cofactors, substrates, proteins, DNAs, and RNAs. Software applications that can mimic the interactions amongst all of these species, taking account of the laws of thermodynamics, would help gain information for understanding qualitatively and quantitatively key determinants contributing to the energetics of the bimolecular recognition process. This, in turn, would allow the design of novel compounds that might bind at the intermolecular interface by either preventing or reinforcing the recognition.
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