AI Article Synopsis
- Prodigiosin (PG), a compound from Serratia marcescens, shows strong cancer-fighting properties and can suppress the immune system.
- The study focused on how mitochondria contribute to PG's ability to trigger apoptosis (cell death) in GLC4 lung cancer cells, using Hoechst 33342 staining for analysis.
- Results indicated that PG activates both caspase-dependent and caspase-independent pathways to induce apoptosis.
Article Abstract
Prodigiosin (PG) is a secondary metabolite, isolated from a culture of Serratia marcescens, which has shown potent cytotoxicity against various human cancer cell lines as well as immunosuppressive activity. The purpose of this study was to evaluate the role of mitochondria in PG-induced apoptosis. Therefore, we evaluated the apoptotic action of PG in GLC4 small cell lung cancer cell line by Hoechst 33342 staining. In these cells, we examined mitochondrial apoptosis-inducing factor (AIF) and cytochrome c (cyt c) release to the cytosol in PG time-response studies. These findings suggest that PG induces apoptosis in both caspase-dependent and caspase-independent pathways.
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| http://dx.doi.org/10.1196/annals.1299.030 | DOI Listing |
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