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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes.
Neoplasia
December 2024
Institute of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Zurich, 8057 Zürich, Switzerland. Electronic address:
Fibrosarcomas (FSA) are malignant mesenchymal tumors characterized by low chemo- and radiosensitivity. Development of novel treatment strategies for human adult FSA is hindered by the low incidence and the absence of suitable clinical models. Interestingly, aggressive FSA occur more frequently in domestic cats, hence potentially representing a clinically amenable model to assess novel therapies such as targeted imaging or theranostics.
View Article and Find Full Text PDFClinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report.
Vet Med Sci
November 2024
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
A 4-year-old white male DSH cat was presented to the Veterinary Hospital on 18 December 2023, with a history of lethargy, loss of appetite, and salivation. During the inspection of the oral cavity, unilateral swelling was observed on the ventral side of the jaw. Before any therapeutic intervention, a cell blood count (CBC) test and FNA cytology were conducted.
View Article and Find Full Text PDFHistopathological changes in testicular lesions in cats.
J Feline Med Surg
September 2024
Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR, China.
Article Synopsis
- - This study examined testicular lesions in cats in Hong Kong from 2018 to 2024, focusing on both neoplastic (tumor-related) and non-neoplastic (non-tumor-related) findings.
- - Out of 26 testis samples from 18 cats, non-neoplastic lesions were more common, especially inflammation and conditions like cryptorchidism, while neoplastic lesions were found in three older cats, including Sertoli cell tumor, leiomyoma, and fibrosarcoma.
- - The research highlights that non-neoplastic lesions are prevalent and identifies new instances of leiomyoma and fibrosarcoma in cats’ testes, suggesting the need for awareness about these possible conditions.
Comparison of MMP-2, MMP-9, COX-2, and PGP Expression in Feline Injection-Site and Feline Noninjection-Site Sarcomas-Pilot Study.
Animals (Basel)
July 2024
Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Feline injection-site sarcomas (FISSs) are aggressive neoplasms that have been associated mostly with vaccination. Feline noninjection-site sarcomas (non-FISSs) are less frequently observed in cats and may arise in any anatomic site. This study aimed to determine the differences in the expression of the selected proteins (matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), cyclooxygenase-2 (COX-2), and P-glycoprotein (PGP)) and their correlation with the mitotic count in FISS and non-FISS, in order to characterize their immunohistochemical features.
View Article and Find Full Text PDFUnlocking immunotherapy targets: programmed death 1 and its ligand and their correlation with tumour grade in feline injection site sarcoma.
J Comp Pathol
August 2024
Health Sciences Institute, Mehmet Akif Ersoy University, Değirmenler, 15200 Yakaköy/Burdur, Türkiye.
In this study, the immunohistochemical expression of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1), which could facilitate a novel approach to immunotherapy for feline injection site sarcomas (FISSs), was investigated. Treatment strategies based on the suppression of this pathway are possible for tumours expressing PD-1/PD-L1. In this context, FISSs were histologically classified, the grade of sarcoma and the intensity of lymphocyte infiltration determined and PD-1 and PD-L1 expression evaluated in tumours of different grade.
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