Background: The possible relationship between serum total cholesterol (TC) levels and outcome following ischemic stroke is still controversial. We evaluated the association between TC levels and 30-day mortality in a sample of older patients with acute ischemic stroke.
Methods: We enrolled 490 older patients with severe ischemic stroke consecutively admitted to University Hospital's Internal Medicine or Geriatrics Department. Stroke type was classified according to the Oxfordshire Community Stroke Project. The data recorded included clinical features, medical history, electrocardiogram, and blood analyses. Patients were divided into three groups by TC levels: group I (TC<4.1 mmol/L), group II (TC 4.1-5.2 mmol/L), and group III (TC>5.2 mmol/L).
Results: The overall mortality was 27.7%. Mortality was higher in patients with low TC levels (47.4%) compared with those with normal and high TC levels (23.0% and 24.1%, respectively). The odds ratio (OR) for short-term death was 2.17 (95% confidence interval [CI] 1.22-3.85) in group I compared with group III, after adjustment for age and gender. This result did not change after adjustment for possible confounders (OR 2.87; 95% CI 1.23-6.68). A similar trend was observed after adjustment for the Oxfordshire classification, age, and gender (OR 1.67; 95% CI 0.83-3.33).
Conclusions: Short-term mortality following ischemic stroke is higher in older participants with low TC levels, independent of a large number of factors. Low TC levels might be useful in identifying frail older participants at high risk of stroke short-term mortality.
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http://dx.doi.org/10.1093/gerona/59.3.m293 | DOI Listing |
BMJ Open
January 2025
Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
Objectives: To investigate the safety and efficacy outcomes of intravenous thrombolysis (IVT) in patients aged >80 years with acute ischaemic stroke (AIS) after IVT was approved in this patient population in several European and non-European countries during 2018-2019.
Design: This is an observational registry study using prospectively collected data from the Safe Implementation of Treatment in Stroke (SITS) registry. Comparisons will be performed between patients treated post-approval (July 2018 to December 2021) period with those treated pre-approval (June 2015 to June 2018) period using propensity score matching (PSM).
J Stroke Cerebrovasc Dis
January 2025
Department of Clincal Sciences, Danderyd hospital, Karolinska Institutet, Stockholm, Sweden.
Background: Stroke patients with large vessel occlusions risk long-term or permanent sickness absence. We aimed to analyze the proportions and days of sickness absence and disability pension in thrombectomy-treated patients.
Methods: A register-based nationwide longitudinal cohort study of stroke patients treated with mechanical thrombectomy in 2016-2021 in Sweden (identified through the Swedish Board of Health and Welfare procedural code for care interventions, KVÅ:AAL15).
Brain
January 2025
Faculty of Social and Behavioural Sciences, University of Amsterdam, 1001 NK, Amsterdam, The Netherlands.
Mid-level visual processing represents a crucial stage between basic sensory input and higher-level object recognition. The conventional model posits that fundamental visual qualities like color and motion are processed in specialized, retinotopic brain regions (e.g.
View Article and Find Full Text PDFPublic Health
January 2025
Department of Neurology, First Affiliated Hospital of Gannan Medical Univesity, Ganzhou, 341000, Jiangxi, China. Electronic address:
Objectives: The aim of this study was to investigate the associations, potential effects, and interactions between short-term exposure to air pollution and the risk of ischemic stroke (IS).
Study Design: An ecological study.
Methods: Daily data on IS incidents, air pollution, and meteorological conditions were collected from 2017 to 2021 in Gannan.
Neurosciences (Riyadh)
January 2025
From the Department of Family and Community Medicine (Mahfouz, Ghazy), College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia, from Alexandria Directorate of Health Affairs (Abdelmoneim), Egyptian Ministry of Health and Population, Alexandria, Department of Public Health and Community Medicine (Abdu), Faculty of Medicine, Mansoura University, Mansoura, from Public Health and Community Medicine (AboElela, Shiba), Faculty of Medicine for Girls, Al-Azhar University, Cairo, Neuroscience Center (Alhazzani), King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Objectives: To describe age-standardized incidence and disability-adjusted life years (DALYs) of ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in the Kingdom of Saudi Arabia (KSA) from 1990 to 2019 and forecast these variables using the Global Burden of Diseases (GBD) data over the next years (2020-2030).
Methods: Poisson regression models were employed to identify significant changes in incidence rate ratios (IRRs) and DALY rates for different stroke types. For time series models, the autoregressive integrated moving average (ARIMA) and exponential smoothing state space (ETS) models were used for forecasting.
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