The final Communication III deals with the pleiotropicaction of the phosphotransferase system (PTS) focusing on the below issues related with the bacterial cell: PTS and the nitrous metabolism regulation, virulence, chemotaxis and sporulation. The factor of protein Mlc within the regulation of PTS itself, i.e. of permease PtsG and of system's general components, is described separately. Therefore, all practically valuable PTS functions involved in the vital activity of both gram-positive and gram-negative bacteria are elucidated; they are depicted in a generalized diagram, Fig. 2, Communication 1.
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Handb Clin Neurol
January 2025
Sleep Medicine Center, Department of Neurology, Villa Serena Hospital, Città S. Angelo, Pescara, Italy; Villaserena Research Foundation, Città S. Angelo, Pescara, Italy.
Advanced sleep phase (ASP) is seldom brought to medical attention because many individuals easily adapt to their early chronotype, especially if it emerges before the age of 30 and is present in a first-degree relative. In this case, the disorder is considered familial (FASP) and is mostly discovered coincidentally in the presence of other sleep disorders, mainly obstructive sleep apnea syndrome (OSAS). The prevalence of FASP is currently estimated to be between 0.
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Clinical and Molecular Medicine Department, School of Medicine and Psychology, Sapienza University of Rome, 00189 Roma, Italy.
A healthy lifestyle plays a key role for maintaining the cardiovascular health (CVH) status and prevent cardiovascular disease occurrence. In fact, a healthy lifestyle was included in the AHA Cardiovascular Health score (Life's Simple 7 [LS7]), subsequently updated to Life's Simple 8 [LS8]. Apart from the importance of controlling conventional cardiovascular risk factors, increasing evidence supports the contributory role of cardiovascular hormones.
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Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.
NupR is a nucleoside permease regulator belonging to the GntR family, mainly regulating nucleoside transport in . A conserved binding site for NupR was found in the promoter region of . This study aimed to investigate the regulation of the virulence regulator PlcR by NupR and its impact on Bt virulence.
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Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Since its discovery, IL-1β has taken center stage as a key mediator of a very broad spectrum of diseases revolving around immuno-mediated and inflammatory events. Predictably, the pleiotropic nature of this cytokine in human pathology has led to the development of targeted therapeutics with multiple treatment indications in the clinic. Following the accumulated findings of IL-1β's central modulatory role in the immune system and the implication of inflammatory pathways in cancer, the use of IL-1β antagonists was first proposed and then also pursued for oncology disorders.
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