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http://dx.doi.org/10.1385/1-59259-753-X:221 | DOI Listing |
J Virol
July 2024
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Unlabelled: Human cytomegalovirus (HCMV) is a β-herpesvirus that poses severe disease risk for immunocompromised patients who experience primary infection or reactivation. Development and optimization of safe and effective anti-HCMV therapeutics is of urgent necessity for the prevention and treatment of HCMV-associated diseases in diverse populations. The use of neutralizing monoclonal antibodies (mAbs) to limit HCMV infection poses a promising therapeutic strategy, as anti-HCMV mAbs largely inhibit infection by targeting virion glycoprotein complexes.
View Article and Find Full Text PDFFront Immunol
August 2023
Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Human cytomegalovirus (HCMV) is a prototypical β-herpesvirus which frequently causes morbidity and mortality in individuals with immature, suppressed, or senescent immunity. HCMV is sensed by various pattern recognition receptors, leading to the secretion of pro-inflammatory cytokines including tumor necrosis factor alpha (TNFα). TNFα binds to two distinct trimeric receptors: TNF receptor (TNFR) 1 and TNFR2, which differ in regard to their expression profiles, affinities for soluble and membrane-bound TNFα, and down-stream signaling pathways.
View Article and Find Full Text PDFMethods Mol Biol
May 2004
Virus Cell Interaction Unit, Mdical Faculty, Martin-Luther-University of Halle-Wittenberg, Halle, Germany.
Uirusu
December 1996
Department of Microbiology, Osaka University Medical School, Japan.
J Gen Virol
September 1991
Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Germany.
The entire genome of human herpesvirus 6 (HHV-6) strain U1102 was cloned as overlapping fragments in cosmid and plasmid vectors. Cleavage maps were constructed for the restriction endonucleases BamHI, EcoRI, NotI and SmaI. The genome of HHV-6 U1102 is a linear dsDNA of 163 kbp, consisting of a long unique 142 kbp region flanked by direct terminal repeats of 10.
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