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Estimated equipotent conversion ratios of morphine, sufentanil and fentanyl as continuous infusion in neonatal intensive care units: a pharmacoepidemiologic cohort study.
Eur J Clin Pharmacol
December 2024
Neonatal Intensive Care Unit, CHI Créteil, 40 Avenue de Verdun, 94000, Créteil, France.
Purpose: Opioids are frequently used to treat pain in neonatal intensive care units (NICU) with fentanyl, morphine and sufentanil being mainly used agents. Equianalgesic potency between opioids is not clearly described in the neonatal population. The aim of this study was to compare theoretical and actual equipotent conversion ratios between morphine, sufentanil and fentanyl based on prescriptions.
View Article and Find Full Text PDFEffects of continuous pecto-intercostal fascial block for management of post-sternotomy pain in patients undergoing cardiac surgery: a randomized controlled trial.
Int J Surg
December 2024
Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Background: Managing postoperative pain following median sternotomy has long been a notable challenge for anesthesiologists. The administration of postoperative analgesia traditionally relies on intravenous pumps for the delivery of opioids. With the development of regional block techniques and postoperative multimodal analgesia, pecto-intercostal fascial block (PIFB) has gained widespread utilization due to its distinctive advantages.
View Article and Find Full Text PDFEffects of paravertebral block on postoperative analgesia in children undergoing unilateral thoracotomy cardiac surgery with cardiopulmonary bypass: protocol for a randomised controlled trial.
BMJ Open
November 2024
Department of Anestheisiology, Fuwai Hospital State Key Laboratory of Cardiovascular Disease, Beijing, China
Introduction: This study aims to determine whether paravertebral block (PVB) provides better postoperative analgesia, lower incidence of complications and faster recovery compared with local anaesthetic wound infiltration for school-aged children undergoing cardiac surgery with cardiopulmonary bypass via thoracotomy.
Method And Analysis: This is a single-centre, randomised controlled trial. We will enrol 100 children aged 6-14 years with atrial or ventricular septal defects scheduled for thoracotomy cardiac surgery with cardiopulmonary bypass.
A prospective cohort study comparing monitored anesthesia care and intubated general anesthesia in cardiac surgery involving cardiopulmonary bypass.
Eur J Med Res
October 2024
Department of Anesthesiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528 of Zhangheng Road, Pudong New Area, Shanghai, 201203, China.
Article Synopsis
- The study evaluated the feasibility and safety of monitored anesthesia care (MAC) versus intubated general anesthesia (IGA) for cardiac surgery involving cardiopulmonary bypass (CPB).
- A total of 11 patients received MAC while 13 received IGA, with no major complications in either group, and both groups showed similar demographic and operative characteristics.
- Results indicated that MAC led to lower opioid use, quicker resumption of oral intake, and reduced ICU length of stay, suggesting MAC may improve postoperative recovery compared to IGA.
Efficacy and safety of esketamine hydrochloride adjunct to sufentanil in non-surgical patients under mechanical ventilation in the ICU (SENSATION trial): protocol for a multicentre, single-blind, randomised controlled trial.
BMJ Open
September 2024
Department of Critical Care Medicine, Nanjing Jinling Hospital, Nanjing, Jiangsu, China
Introduction: Pain is common in patients receiving mechanical ventilation in the intensive care unit (ICU). Intravenous opioids are recommended as first-line therapy for pain management; however, opioids have adverse side effects. Based on low-quality evidence, low-dose ketamine is therefore recommended as an opioid adjunct to reduce opioid consumption.
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