AI Article Synopsis
- The study aimed to see if alpha-tocopherol, a compound that scavenges reactive oxygen species (ROS), can reduce oxidative stress and interleukin-6 (IL-6) production triggered by lipopolysaccharide (LPS) in mouse microglia and the brain.
- LPS exposure resulted in increased levels of intracellular peroxides and IL-6 in microglia, but pretreating with alpha-tocopherol significantly lowered these increases.
- Administering three daily injections of alpha-tocopherol to mice not only raised its levels in the brain but also reduced LPS-induced lipid peroxidation and IL-6 production, suggesting it can help decrease inflammation in the brain.
Article Abstract
The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The LPS-induced increase in ROS and IL-6 was reduced by pretreatment of alpha-tocopherol. Intraperitoneal injection (i.p.) of LPS induced lipid peroxidation and IL-6 in brain. Importantly, three daily injections (20 mg) of alpha-tocopherol increased brain alpha-tocopherol and decreased LPS-induced lipid peroxidation and IL-6 in brain. Taken together, these data indicate that alpha-tocopherol can mitigate inflammatory cytokine production in the brain.
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| http://dx.doi.org/10.1016/j.jneuroim.2003.12.017 | DOI Listing |
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