A protocol is described for validation of implanted oxygen sensors, in which sensors are calibrated in the gas phase where concentration boundary layers are absent. Calibration prior to sensor implantation and confirmation after sensor explantation allows separation of tissue mass transfer effects from sensor variance and drift. A model is given here that describes the oxygen-dependent signal current in terms of oxygen mass transfer to the sensor, permeability of the sensor membrane, and electrode area. The parameter used in the model to describe mass transfer to implanted sensors is consistent with experimental observations and allows comparisons with nonimplanted sensors. This method provides a bridge between the complementary approaches of empirical calibration and model-based calculation for determining oxygen concentration from the sensor response.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ac0352169 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer-a retrospective cohort study.
J Assist Reprod Genet
January 2025
Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Purpose: To assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET).
Methods: This is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer at two tertiary reproductive medicine centres from 2019 to 2021. Only the first frozen embryo transfer was included for women who had repeated transfers during the period.
Biomarkers.
Alzheimers Dement
December 2024
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South).
Background: Plasma biomarkers for Alzheimer's disease (AD) have demonstrated their accuracy as diagnostic tools, suggesting their impending integration into clinical practice. Medical comorbidities might not only affect AD pathological burdens but also cause variability of plasma biomarkers by affecting their transfer via blood brain barriers. In the present study, we aimed to determine which comorbidities might affect plasma biomarkers with (real effects) or without (biological variability) AD pathological burdens measured by β-amyloid (Aβ) uptakes on PET.
View Article and Find Full Text PDFUnravelling sources of variability on rocuronium pharmacokinetics: Implications for prolonged recovery in older patients.
Br J Clin Pharmacol
January 2025
Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics. College of Pharmacy, University of Florida, Orlando, FL, USA.
Aims: Residual neuromuscular blockade (RNB) commonly occurs when using neuromuscular blockers and increases the risk for pulmonary complications, such as airway obstruction and severe hypoxemia, in extubated patients. Rocuronium exhibits a high variability in recovery time, contributing to an increased risk for RNB. This study aimed to identify and characterize the sources of variability in rocuronium exposure and response via a population pharmacokinetic/pharmacodynamic (PK/PD) analysis and to apply the developed PK/PD model to investigate clinical implications.
View Article and Find Full Text PDFBackground: Recent studies have revealed that tRNA-derived fragments(tRFs)are closely associated with the immunoinflammatory process of brain injury after stroke.
Method: Firstly, 3 patients with WMI and the same number of healthy volunteers' peripheral blood in the control group were collected. EVS in the subjects' peripheral plasma was isolated and purified, and tRFs high-throughput sequencing was performed.
Background: African Americans bear a disproportionate burden of both cardiovascular diseases and Alzheimer's disease (AD). Assessment of the Five-Factor personality dimensions-Neuroticism, Extroversion, Openness, Agreeableness, and Conscientiousness, particularly, higher levels of neuroticism-is linked to greater adverse cardiovascular and cognitive outcomes, including AD. Generalization-the ability to apply prior learning to new circumstances-is presented as a putative cognitive marker for the earliest stages of preclinical AD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!