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Pharmacological Triggers of Takotsubo Cardiomyopathy: An Updated Review of Evidence and Recommendations.

Curr Cardiol Rev

April 2024

Department of Pharmacy Practice, J.K.K.Nattraja College of Pharmacy, Kumarapalayam, Namakkal district, Tamilnadu, India.

Background: Previous publications in 2011, 2016, and 2022 have presented lists of drugs associated with takotsubo cardiomyopathy (TCM). This review aims to provide updated drug lists that have been reported as potential causes of TCM.

Methods: Following the same methodology employed in previous reviews, a detailed investigation was carried out in the PubMed/Medline database from June 2022 to July 2023 to identify drug-induced TCM (DITC) case reports.

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Drugs as Possible Triggers of Takotsubo Cardiomyopathy- Update 2022: Systematic Review.

Curr Vasc Pharmacol

November 2023

Grupo de Investigación, Promoción y Prevención Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín, Colombia.

Article Synopsis
  • A review was conducted to update the list of drugs that can cause takotsubo cardiomyopathy (TCM), a condition often linked to stress and emotional triggers.
  • From April 2015 to May 2022, 184 manuscripts were reviewed, leading to the identification of 39 articles that recognized drugs associated with TCM, revealing a total of 72 drugs in this updated list.
  • While some of the identified drugs are known to cause sympathetic overstimulation, others in the list do not clearly correlate with this mechanism, indicating a need for further research.
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A systematic cohort review of pheochromocytoma-induced typical versus atypical Takotsubo cardiomyopathy.

Int J Cardiol

January 2023

Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Endocrine Surgery, National University Hospital, Singapore. Electronic address:

Background: A rare presentation of pheochromocytoma (PCC) is catecholamine-induced-cardiomyopathy, or Takotsubo cardiomyopathy (TCM). PCC-induced TCM(PCC-TCM) can present as a typical or atypical type, based on the location of cardiac wall motion abnormalities. In this review, we sought to assess features and outcomes for PCC-TCM, and to compare typical and atypical subtypes.

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Takotsubo syndrome in patients with myasthenia gravis: a systematic review of previously reported cases.

BMC Neurol

November 2019

Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.

Background: Myasthenia gravis associated takotsubo syndrome is a rare condition. This study aimed to explore its typical presentation, investigations and treatment through a systematic review of previously reported cases.

Methods: Databases and reference lists of the selected articles were searched for case reports on Myasthenia gravis associated takotsubo syndrome.

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Takotsubo cardiomyopathy (TC) is characterized by transient wall motion abnormalities most commonly involving the left ventricle (LV). Although biventricular TC had been considered uncommon condition, recently biventricular TC has been reported as a new variant observed in 19-42% of all TC presentations. Since biventricular TC has a poor prognosis as compared with isolated TC, it is important to distinguish between isolated LV TC and biventricular TC.

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