Background & Aims: Combined multichannel intraluminal impedance and manometry (MII-EM) assesses esophageal function by simultaneous measurement of both pressure and bolus transit. Normative data for this method have not been published. The aim of this study was to establish normative data for combined MII-EM and to correlate liquid and viscous bolus transit by impedance with esophageal contractions by manometry.
Methods: Forty-three normal volunteers recruited from 4 centers (15 women, 28 men; age range, 21-72 years) underwent combined MII-EM with a catheter containing 4 impedance-measuring segments and 4 solid-state pressure transducers. Each center recruited and analyzed subjects independently, according to pre-established criteria. Each subject received 20 x 5 mL swallows, 10 liquid and 10 viscous material. Tracings were analyzed manually for bolus presence time, bolus head advance time, segmental transit times, total bolus transit time, contraction amplitude, duration, and onset velocity.
Results: Ninety-seven and four-tenths percent of manometrically normal liquid and 96.1% of manometrically normal viscous swallows had complete bolus transit by impedance. Almost half (47.2%) of manometrically ineffective liquid and 34.7% of ineffective viscous swallows had complete bolus transit, whereas 91.7% of manometric simultaneous liquid swallows and 54.5% of simultaneous viscous swallows had complete bolus transit. More than 93% of normal individuals had at least 80% complete liquid or at least 70% complete viscous bolus transit.
Conclusions: This study establishes normative data for combined MII-EM. Combined MII-EM may be a more sensitive tool in assessing esophageal function compared to standard manometry because impedance can distinguish different bolus transit patterns. Studies in patients with manometrically defined esophageal motility abnormalities should help clarify the functional importance of manometric ineffective and simultaneous swallows.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1053/cgh.2003.50026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of mid vs distal left anterior descending artery measures in coronary physiology assessment.
Cardiovasc Revasc Med
December 2024
Department of Internal Medicine and Division of Cardiology, Baylor Scott and White, Temple, TX, United States of America. Electronic address:
Background: Angina with no obstructive coronary artery disease (ANOCA) occurs in approximately 40 % of patients who undergo diagnostic coronary angiography for symptoms of angina. Coronary physiology assessment (CPA) is a guideline proven method to assess and diagnose these patients for an effective treatment strategy. There is currently no data regarding optimal wire or sensor position for CPA using bolus coronary thermodilution.
View Article and Find Full Text PDFThe Impact of Bolus Rheology on Physiological Swallowing Parameters Derived by Pharyngeal High-Resolution Manometry Impedance.
Neurogastroenterol Motil
December 2024
Trisco Foods, Carole Park, Queensland, Australia.
Article Synopsis
- The study examines how the rheology (flow behavior) of ingested fluids affects swallowing and the physiological responses during deglutition, specifically comparing xanthan gum (XG) and sodium carboxymethylcellulose gum (CMC) in healthy adults.
- Results showed that CMC had significantly higher viscosity than XG at higher shear rates (300 s), leading to increased flow resistance during swallowing, indicated by higher intrabolus pressure and altered relaxation times of the upper esophageal sphincter (UES).
- The findings suggest that the differences in shear viscosity of these fluids affect pharyngeal function during swallowing, highlighting the importance of fluid properties over standardized viscosity levels (IDDSI).
Nurse-led therapeutic patient education program on glycemic control and emotional wellbeing in adolescents with type 1 diabetes mellitus during hospital transition.
Endocrinol Diabetes Nutr (Engl Ed)
January 2025
Universidad de Sevilla, Sevilla, Spain.
Introduction: The transition of adolescents from pediatric to adult hospitals is a planned and guided process that involves changes in the focus, style, and location of care. During this period, complications are common in those with type 1 diabetes mellitus (T1DM). The objective of this study was to understand the influence of a nurse-led structured therapeutic education program on maintaining glycemic control and emotional wellbeing in these adolescents.
View Article and Find Full Text PDFArticle Synopsis
- * She was diagnosed with hyperglycemia and ketosis, treated for diabetic ketoacidosis (DKA) with insulin, and later transitioned to an insulin regimen after discharge.
- * The case is significant for recognizing immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) as a potential side effect of immunotherapy, leading to the discontinuation of her cancer treatment and planning for surgery.
Objective: Assessment of feasibility and proof of concept study for microvascular reactivity in anesthetized cats.
Methods: 12, adult, healthy, purpose-bred cats were included. Cats were anesthetized and instrumented with a perivascular ultrasound transit time flow probe around the main pulmonary artery, a femoral arterial catheter, a central venous catheter, and a laser Doppler flowmeter with a heating unit.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!