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| http://dx.doi.org/10.1136/bmj.328.7440.634 | DOI Listing |
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Imaging Approach to Pulmonary Hypertension.
Radiol Clin North Am
March 2025
Department of Radiology and Biomedical Imaging, University of California San Francisco, M-391 Box 0628, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
Pulmonary hypertension is a rare but important clinical problem that presents a sometimes challenging diagnostic dilemma. The diagnosis of pulmonary hypertension relies on a combination of clinical testing and radiologic imaging, with chest computed tomography (CT) often serving as the primary imaging modality for comprehensive evaluation of the chest. Chest CT can be used to evaluate for causes of pulmonary hypertension including chronic lung disease, pulmonary artery obstruction, and congenital heart disease.
View Article and Find Full Text PDFThe Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development.
Front Biosci (Landmark Ed)
January 2025
School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, SE5 9NU London, UK.
Cardiovascular disease (CVD) is the most prevalent cause of mortality and morbidity in the Western world. A common underlying hallmark of CVD is the plaque-associated arterial thickening, termed atherosclerosis. Although the molecular mechanisms underlying the aetiology of atherosclerosis remain unknown, it is clear that both its development and progression are associated with significant changes in the pattern of DNA methylation within the vascular cell wall.
View Article and Find Full Text PDFObesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones : Short title: Obesity induces sex-specific responses in mesenteric PVAT.
Cardiovasc Diabetol
January 2025
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK.
Background: Obesity, a major risk factor for cardiovascular disease (CVD), is associated with hypertension and vascular dysfunction. Perivascular adipose tissue (PVAT), a metabolically active tissue surrounding blood vessels, plays a key role in regulating vascular tone. In obesity, PVAT becomes dysregulated which may contribute to vascular dysfunction; how sex impacts the remodelling of PVAT and thus the altered vascular contractility during obesity is unclear.
View Article and Find Full Text PDFNon-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study.
Eye (Lond)
January 2025
Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.
Background/objectives: Idiopathic intracranial hypertension (IIH) is a disease which threatens vision and causes disabling headaches, affecting women of childbearing age with obesity. It is characterised by raised intracranial pressure (ICP), measured invasively either with lumbar punctures or intracranially-inserted monitors. There is an unmet clinical need to develop non-invasive means to assess ICP.
View Article and Find Full Text PDFA two-branch framework for blood pressure estimation using photoplethysmography signals with deep learning and clinical prior physiological knowledge.
Physiol Meas
January 2025
Sichuan University - Wangjiang Campus, No.24 South Section 1, Yihuan Road, Chengdu, Sichuan, 610065, CHINA.
Objective: This paper presents a novel dual-branch framework for estimating blood pressure (BP) using photoplethysmogram (PPG) signals. The method combines deep learning with clinical prior knowledge and models different time periods (morning, afternoon, and evening) to achieve precise, cuffless BP estimation.
Approach: Preprocessed single-channel PPG signals are input into two feature extraction branches.
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