AI Article Synopsis
- * In SNU-719, key EBV genes like EBNA1 and LMP2A are expressed, while other important genes such as LMP1 and EBNA2 are absent; lytic EBV proteins only appear when stimulated.
- * The findings indicate that EBV can infect gastric epithelial cells independently of the CD21 receptor, suggesting that SNU-719 closely mirrors the latent gene expression seen in EBV-associated gastric cancer, making it an important resource for research.
Article Abstract
In a process seeking out a good model cell line for Epstein-Barr virus (EBV)-associated gastric cancer, we found that one previously established gastric adenocarcinoma cell line is infected with type 1 EBV. This SNU-719 cell line from a Korean patient expressed cytokeratin without CD19 or CD21 expression. In SNU-719, EBNA1 and LMP2A were expressed, while LMP1 and EBNA2 were not. None of the tested lytic EBV proteins were detected in this cell line unless stimulated with phorbol ester. EBV infection was also shown in the original carcinoma tissue of SNU-719 cell line. Our results support the possibility of a CD21-independent EBV infection of gastric epithelial cells in vivo. As the latent EBV gene expression pattern of SNU-719 closely resembles that of the EBV-associated gastric cancer, this naturally derived cell line may serve as a valuable model system to clarify the precise role of EBV in gastric carcinogenesis.
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| http://dx.doi.org/10.1016/j.virol.2003.12.005 | DOI Listing |
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