[Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora].

Objective: To compare the antibacterial effects of Huangqin-Tang with its metabolites produced by intestinal flora.

Method: The antibacterial tests in vitro and in vivo were performed by agar dilution method and lethal protection of animal respectively.

Result: Huangqin-Tang and its metabolites had antibacterial action on bacteria in vitro, however the antibacterial activity of metabolites of Huangqin-Tang on Salmomella, Dysentery bacillus and Proteus in vitro was stronger than Huangqin-Tang. The metabolites of Huangqin-Tang had protective effect on the animals infected by Staphylococcus aureus and Escherichia coli respectively from death, but Huangqin-Tang had no lethal protection action.

Conclusion: The antibacterial effects of metabolites of Huangqin-Tang in vitro and in vivo are stronger than that of Huangqin-Tang, which shows that intestinal flora play a very important role in antibacterial effects of Huangqin-Tang.