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Intensity-modulated radiotherapy (IMRT) is a novel conformal radiotherapy technique which is gaining increasing clinical use worldwide. This article aims to summarize the published data pertaining to clinical indications of this therapy for head and neck, central nervous system, and lung tumours. The main indications in head and neck cancer are parotid gland sparing and dose escalation to tumours close to organs at risk. For central nervous system tumours, IMRT has been used to reduce normal tissue radiation by more conformal dose distributions. To date, the majority of reports concern patients treated in the context of clinical trials, and for most tumour types longer term follow up of treated patients will be required to confirm the clinical benefits of IMRT.
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http://dx.doi.org/10.1259/bjr/84246820 | DOI Listing |
Background: Eye tumors are moving targets, but there have been no reports of radiation therapy with real-time monitoring.
Case: A 54-year-old woman with metastatic breast cancer was referred for treatment of diplopia due to choroidal metastasis after hippocampal avoiding whole brain radiotherapy. Since visual acuity was preserved and long-term survival was expected, real-time MRI-guided intensity-modulated radiation therapy (36 Gy in 20 fractions) was performed.
Radiat Oncol
March 2025
Department of Radiation Oncology, Justus-Liebig-University Giessen, Giessen-Marburg University Hospital, Giessen, Klinikstraße, Germany.
Objective: To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, and spinal cord constraints and planning target volume (PTV) coverage intent.
Methods And Materials: A total of 27 patients with stage IIIA/B NSCLC treated with curative intent RT were selected for this analysis. All existing radiation plans were revised and 27 further new equivalent plans were calculated using AHS for the same cohort of patients.
Radiol Phys Technol
March 2025
Department of Radiological Technology, Asahikawa Medical University Hospital, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.
This study aimed to survey technical variations in total body irradiation (TBI) across Japan. A web-based questionnaire investigating technical aspects (irradiation method, in vivo dosimetry, organ shielding, and boluses) of TBI was distributed via the authors' acquaintances in each region of Japan using snowball sampling, and 73 institutions responded. The data were collected from January to April 2024.
View Article and Find Full Text PDFCureus
February 2025
Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, USA.
Intensity-modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC) is associated with acute and late toxicities that impact patient quality of life. Proton radiotherapy (PRT) can reduce exposure to surrounding tissues, but the clinical magnitude of this advantage is unclear. A systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFJ Appl Clin Med Phys
March 2025
School of Physics, University of Melbourne, Melbourne, Australia.
Background: The advent of volumetric modulated arc therapy (VMAT) in radiotherapy has made it one of the most commonly used techniques in clinical practice. VMAT is the delivery of intensity modulated radiation therapy (IMRT) while the gantry is in motion, and existing literature has shown it has decreased treatment delivery times and the number of monitor units without sacrificing coverage. It has previously been shown that for IMRT, multi-leaf collimators (MLC) with narrower leaf widths produce demonstrably higher treatment plan quality.
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