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Case report: targeted therapy of malignant pleural mesothelioma with anaplastic lymphoma kinase receptor tyrosine kinase gene fusion mutation by crizotinib.
J Int Med Res
November 2024
Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan Province, China.
Malignant mesothelioma is a rare highly invasive tumour originating from the mesothelial cells of the pleura, peritoneum and pericardium. Malignant pleural mesothelioma (MPM) is the most common type in all malignant mesothelioma. The onset of MPM is associated with exposure to asbestos and it can have an incubation period of up to 40 years.
View Article and Find Full Text PDFA Case of Malignant Pleural Mesothelioma With Unknown Asbestos Exposure.
Cureus
September 2024
Oncology, Medical City Dallas Hospital, Dallas, USA.
Malignant pleural mesothelioma (MPM) is a rare, locally invasive tumor that develops from mesothelial cells lining the lung's pleura. It is mostly associated with prolonged asbestos exposure. The long latency period between asbestos exposure and clinical symptoms makes diagnosing MPM challenging.
View Article and Find Full Text PDFMalignant Mesothelioma: Overcoming Diagnostic Hurdles.
Cureus
September 2024
Department of Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Malignant pleural mesothelioma (MM) is a severe cancer often caused by asbestos exposure and is typically diagnosed at later stages.
- A 58-year-old mason experienced symptoms such as chest pain, shortness of breath, and weight loss, leading to imaging tests that showed abnormalities in the pleura and lymph nodes.
- Despite initial negative biopsy results, MM was confirmed through a targeted ultrasound-guided biopsy of a lymph node, using specific staining to identify the cancer cells.
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration.
Arch Toxicol
December 2024
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Article Synopsis
- - Fullerene whiskers (FLWs) and fullerenes (FLs) are rod-like structures made of carbon, and their shape raises concerns about potential health risks similar to those posed by asbestos and carbon nanotubes, but no long-term studies on their carcinogenic effects have been conducted.
- - In a study, male rats were given FL, FLW, and different types of multi-walled carbon nanotubes (MWCNT) to assess lung and pleural carcinogenicity, leading to analyses at 1 and 104 weeks post-exposure.
- - Results showed that while MWCNT exposure led to significant increases in lung tumors and oxidative DNA damage, FL and FLW did not induce carcinogenic effects in the
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