AI Article Synopsis
- The study examined how tiazofurin (TR), a purine nucleoside analogue, affects the locomotor and stereotypic activities in adult male Wistar rats.
- Neither low nor high doses of TR affected the rats' normal movement compared to those treated with saline.
- However, TR did significantly reduce locomotor activity induced by amphetamine (AMPH) at almost all doses (except the lowest), suggesting that TR may alter motor activity regulation by impacting dopaminergic transmission.
Article Abstract
The effects of tiazofurin (TR; 2-beta-d-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.
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| http://dx.doi.org/10.1016/j.pbb.2003.12.025 | DOI Listing |
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