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The burden of headache disorders in the adult population of Morocco: estimates, and a health-care needs assessment, from a cross-sectional population-based door-to-door survey.
J Headache Pain
December 2024
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Edvard Griegs gate, Trondheim, Norway.
Background: We have previously shown headache disorders to be prevalent in in the adult general population of Morocco, especially migraine (30.8%) and headache on ≥ 15 days/month (H15+; 10.5%).
View Article and Find Full Text PDFImproving outcomes for very preterm babies in England: does place of birth matter? Findings from OPTI-PREM, a national cohort study.
Arch Dis Child Fetal Neonatal Ed
December 2024
Nuffield Department of Population Health, University of Oxford National Perinatal Epidemiology Unit, Oxford, UK.
Objective: Babies born between 27 and 31 weeks of gestation contribute substantially towards infant mortality and morbidity. In England, their care is delivered in maternity services colocated with highly specialised neonatal intensive care units (NICU) or less specialised local neonatal units (LNU). We investigated whether birth setting offered survival and/or morbidity advantages to inform National Health Service delivery.
View Article and Find Full Text PDFThe importance of microbiology reference laboratories and adequate funding for infectious disease surveillance.
Lancet Digit Health
December 2024
Nuffield Department of Population Health, University of Oxford, Oxford, UK. Electronic address:
Microbiology reference laboratories perform a crucial role within public health systems. This role was especially evident during the COVID-19 pandemic. In this Viewpoint, we emphasise the importance of microbiology reference laboratories and highlight the types of digital data and expertise they provide, which benefit national and international public health.
View Article and Find Full Text PDFAn Intervention into the Diverse Utilities of Fluorenes: A Brobdingnagian Family.
Top Curr Chem (Cham)
December 2024
Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, 690525, India.
The keyword "Fluorene" search in SciFinder found more than 57,000 results, including high-impact journal articles, review articles, patents, books, proceedings, etc. Against this background, a detailed enquiry has been made by our group on various classes of fluorenes and their relevancy. For the past several decades, fluorene and its related compounds have experienced extensive studies, which are attributed to the vast range of applications they possess in various fields like sensors, polymers, OLED devices and even in the pharmaceutical industries.
View Article and Find Full Text PDFOpen-Label, Multicenter, Phase I Study to Assess Safety and Tolerability of Adavosertib Plus Durvalumab in Patients with Advanced Solid Tumors.
Target Oncol
November 2024
Sarah Cannon Research Institute, Nashville, TN, USA.
Background: Adavosertib (AZD1775) is a small-molecule Wee1 inhibitor. Durvalumab is a PD-L1 inhibitor.
Objective: The safety, tolerability, pharmacokinetics, and preliminary antitumor activity of adavosertib plus durvalumab were evaluated in patients with refractory solid tumors to define the maximum tolerated dose (MTD) and recommended phase II dose (RP2D).
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