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Adverse reactions to radiological contrast media: Prevention and treatment.
Radiologia (Engl Ed)
October 2024
Servicio de Alergia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-P), Madrid, Spain. Electronic address:
Radiological contrast media, both iodinated and gadolinium-based, can lead to adverse reactions. Type A reactions are related to the pharmacological characteristics of the contrast, including side, secondary and toxic effects. Post-contrast acute kidney injury is the most frequent adverse reaction to iodinated contrast media.
View Article and Find Full Text PDFResearch progress of nitroxide radical-based MRI contrast agents: from structure design to application.
J Mater Chem B
January 2025
Shenzhen University General Hospital, Shenzhen, China.
Magnetic resonance imaging (MRI) remains a cornerstone of diagnostic imaging, offering unparalleled insights into anatomical structures and pathological conditions. Gadolinium-based contrast agents have long been the standard in MRI enhancement, yet concerns over nephrogenic systemic fibrosis have spurred interest in metal-free alternatives. Nitroxide radical-based MRI contrast agents (NO-CAs) have emerged as promising candidates, leveraging their biocompatibility and imaging capabilities.
View Article and Find Full Text PDFASNR Statement on Gadolinium-Based Contrast Agent Use in Patients with Chronic Kidney Disease.
AJNR Am J Neuroradiol
September 2024
From the Department of Radiology, Mayo Clinic, Rochester MN, USA (K.M.W), Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA (D.J.), Department of Radiology, Loyola University Medical Center, Maywood, IL, USA (A.W.K), Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA (D.S.L.), Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA (A.M.S., C.S), Department of Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA (N.Y.), and Department of Radiology, Providence Little Company of Mary Medical Center, Torrance, CA, USA (J.E.J.).
Article Synopsis
- Since 2006, neuroradiologists have restricted the use of gadolinium-based contrast agents (GBCAs) in patients with chronic kidney disease (CKD) to prevent nephrogenic systemic fibrosis (NSF), significantly reducing its occurrence.
- In 2023-2024, the American Society of Neuroradiology reviewed recent research on GBCA safety to update guidelines for MRI contrast use in CKD patients.
- The ASNR now recommends that Group II GBCAs can be safely used in CKD patients when necessary for diagnosis, and additional safety measures like checking renal function may be relaxed.
Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.
Front Physiol
August 2024
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Lithium (Li) therapy is a valuable tool in psychiatric practice that remains underutilized due to safety concerns. Excessive plasma Li levels are nephrotoxic and can trigger a local immune response. Our understanding of the immunomodulatory effects of Li in the kidney is fragmentary.
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