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A feasibility study of automating radiotherapy planning with large language model agents.
Phys Med Biol
March 2025
Faculty of Business Information, Shanghai Business School, 123 Fengpu Blvd, Shanghai, 201499, CHINA.
: Radiotherapy planning requires significant expertise to balance tumor control and organ-at-risk (OAR) sparing. Automated planning can improve both efficiency and quality. This study introduces GPT-Plan, a novel multi-agent system powered by the GPT-4 family of large language models (LLMs), for automating the iterative radiotherapy plan optimization.
View Article and Find Full Text PDFDecriminalization undone: Assessing the amendment to British Columbia's decriminalization of personal drug possession framework.
Can J Public Health
March 2025
Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
The Province of British Columbia (BC) is in the midst of an ongoing public health emergency, declared in 2016 in response to significant levels of drug poisonings/overdoses stemming from the unregulated drug supply. In response, BC implemented decriminalization in 2023, removing criminal sanctions for adults possessing up to 2.5 cumulative grams of opioids, cocaine, methamphetamine, and MDMA.
View Article and Find Full Text PDFBackground: People with cystic fibrosis (pwCF) often have multifactorial peripheral muscle abnormalities attributed to, for example, malnutrition, steroid use, altered redox balance and, potentially, CF-specific intrinsic alterations. Malnutrition in CF now includes an increasing prevalence of overweight and obesity, particularly in those receiving CF transmembrane conductance regulator (CFTR) modulator therapy (CFTRm). We aimed to characterise peripheral muscle function and body composition in pwCF on Elexacaftor/Tezacaftor/Ivacaftor (ETI) CFTRm, compared to healthy controls.
View Article and Find Full Text PDFREM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness.
J Biomed Sci
March 2025
GIGA-Institute, CRC-Human Imaging, University of Liège, Bâtiment B30, 8 Allée du Six Août, Sart Tilman, 4000, Liège, Belgium.
Background: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we investigated if the in vivo activity of the LC is related to the variability in the quality of Rapid Eye Movement (REM) sleep.
View Article and Find Full Text PDFHybrid AHP-VIKOR methodology for multi-criteria decision-making in marine renewable energy systems: Optimizing DC-DC buck converters for sustainable offshore applications.
Mar Pollut Bull
March 2025
Sanya Research Institute of Hunan University of Science and Technology, Sanya 572000, China. Electronic address:
The increasing demand for sustainable offshore energy solutions necessitates efficient power conversion technologies that minimize environmental impact while ensuring reliable energy delivery. The DC-DC buck converter plays a crucial role in marine renewable energy systems, optimizing power conversion for offshore wind, wave, and floating solar applications. However, selecting the most efficient and sustainable converter requires balancing efficiency, reliability, cost, thermal performance, and size under harsh marine conditions.
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