AI Article Synopsis
- The study examines factors influencing tumor control probability (TCP) after 3D conformal hypofractionated high-dose radiotherapy for small lung and liver tumors.
- A total of 34 patients with 42 tumors were treated, and the 2-year TCP was found to be 83.6%, with tumor size being the significant predictor of TCP.
- The findings indicate that smaller tumors (less than 3 cm) had a much higher TCP (95.0%) compared to larger tumors (58.3%) and no severe side effects were reported.
Article Abstract
Purpose: To show the factors correlated with tumor control probability (TCP) after three-dimensional conformal hypofractionated high-dose radiotherapy (3D-CHHRT) for small pulmonary or hepatic tumors.
Methods And Materials: We enrolled 34 patients with 42 lesions (13 lung carcinomas, 6 hepatocellular carcinomas, and 23 lung or liver metastases) treated with 3D-CHHRT alone, with simple immobilization devices, between July 1997 and January 2002. We prescribed 45 Gy in three fractions at the 90-100% isodose line of the planning target volume. The median follow-up period was 18 months (range, 4-46 months). We calculated the TCP using the Kaplan-Meier method and univariate analysis for the following factors: age, gender, primary site, histologic type, tumor size, and previous treatment.
Results: Overall, the 2-year TCP of 3D-CHHRT was 83.6%. Local recurrence was observed in 6 lesions within 1 year after treatment. We showed that tumor size was the only significant factor to correlate with the TCP in univariate analysis. The 2-year TCP for tumors <3 cm or > or =3 cm in diameter was 95.0% and 58.3%, respectively (p = 0.0022). No severe adverse effects were observed.
Conclusion: The TCP for tumors <3 cm in diameter was excellent for 3D-CHHRT.
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| http://dx.doi.org/10.1016/j.ijrobp.2003.08.012 | DOI Listing |
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