Olfactory receptor gene expression.

Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory chemospecificity, ranging from chromosomal localization and control of expression of olfactory receptor genes to temporal and spatial expression patterns of various receptor types in the nasal neuroepithelium. The target-independent onset of receptor expression and its topographical organization suggest a precommited functional identity of olfactory neurons.