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Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease.
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January 2025
Immunology, University of Toronto, Toronto, Ontario, Canada.
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecules that comprise the acellular milieu of tissues. Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function.
View Article and Find Full Text PDFReinforcing Bulk Heterojunction Morphology through Side Chain-Engineered Pyrrolopyrrole-1,3-dione Polymeric Donors for Nonfullerene Organic Solar Cells.
ACS Appl Energy Mater
January 2025
School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Organic solar cells (OSCs) are attracting significant attention due to their low cost, lightweight, and flexible nature. The introduction of nonfullerene acceptors (NFAs) has propelled OSC development into a transformative era. However, the limited availability of wide band gap polymer donors for NFAs poses a critical challenge, hindering further advancements.
View Article and Find Full Text PDFRPRD1B's direct interaction with phosphorylated RNA polymerase II regulates polyadenylation of cell cycle genes and drives cancer progression.
RSC Chem Biol
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Department of Molecular Biosciences, University of Texas Austin Texas USA
RNA polymerase II (Pol II) regulates eukaryotic gene expression through dynamic phosphorylation of its C-terminal domain (CTD). Phosphorylation at Ser2 and Thr4 on the CTD is crucial for RNA 3' end processing and facilitating the recruitment of cleavage and termination factors. However, the transcriptional roles of most CTD-binding proteins remain poorly understood.
View Article and Find Full Text PDFUropygial gland microbiota of nearctic-neotropical migrants vary with season and migration distance.
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Department of Biochemistry, The University of Western Ontario, 1151 Richmond St., London, ON, N6A 5C1, Canada.
Symbiotic microbiota are important drivers of host behaviour, health, and fitness. While most studies focus on humans, model organisms, and domestic or economically important species, research investigating the role of host microbiota in wild populations is rapidly accumulating. Most studies focus on the gut microbiota; however, skin and other glandular microbiota also play an important role in shaping traits that may impact host fitness.
View Article and Find Full Text PDFExploring the influence of pregnancy on cognitive function in women: a systematic review.
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Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Background: Pregnancy has been increasingly recognized for its potential impact on cognitive function influenced significantly by hormonal fluctuations such as estrogen and progesterone. However, the findings from research in this area remain debated, often varying with individual factors and pregnancy trimesters.
Objective: This study aims to systematically review existing literature and empirical research to better understand the phenomenon known as "pregnancy brain" and its association with cognitive change.
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