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Persistent COVID-19 improved with immunoglobulin replacement therapy in Good's syndrome.
Respir Investig
January 2025
Department of Respiratory Medicine, Kyoto Katsura Hospital, 17 Yamadahirao-cho, Nishikyo-ku, Kyoto, 615-8256, Japan.
A 69-year-old man with a history of thymoma resection was diagnosed with COVID-19 pneumonia. Initially, the patient responded well to molnupiravir, but he experienced a relapse. Subsequent steroids for COVID-19-related organizing pneumonia (OP) led to temporary improvement, but his condition deteriorated when the steroids were tapered off.
View Article and Find Full Text PDFCOVID-19 and Good's Syndrome After Thymectomy.
Cureus
September 2024
General Medicine, King's College Hospital NHS Foundation Trust, London, GBR.
Good's syndrome is a rare secondary immunodeficiency characterised by recurrent infection and hypogammaglobulinemia associated with thymus tumour, and symptoms of recurrent infection may persist even after thymectomy. It is characterised by increased susceptibility to bacterial, viral, and fungal infections, as well as autoimmunity. Immunoglobulin replacement therapy has been reported to decrease infection rate, hospitalization, and the rate of antibiotic use in these patients.
View Article and Find Full Text PDFB cell deficiency in thymoma tissues of Good's syndrome patients.
Discov Oncol
October 2024
Department of Clinical Laboratory, South China Hospital, Medical School, Shenzhen University, 1 Fuxin Road, Shenzhen, 518111, China.
Objectives: Good's syndrome (GS) is a rare secondary immunodeficiency which is characterized by hypogammaglobulinemia and thymoma. This study aims to investigate the expression and distribution of B cells in thymoma tissue, given that B cells had been found to be reduced or absent in peripheral blood or bone marrow.
Methods: This study retrospectively analyzed thymoma tissues from 5 GS patients at the First Affiliated Hospital of Wenzhou Medical University and Zhejiang Provincial People's Hospital.
Thymoma-Related Chest Pain and Dyspnea in a Middle-Aged Caucasian Female With Myasthenia Gravis and Good's Syndrome: A Case Report.
Cureus
August 2024
Department of Obstetrics and Gynecology, South Central Regional Medical Center, Laurel, USA.
Thymomas are rare tumors originating from thymic tissue, often associated with various paraneoplastic syndromes that can pose significant clinical management challenges. Myasthenia gravis, one of the most common paraneoplastic syndromes linked to thymomas, is characterized by autoantibodies targeting the neuromuscular junction, leading to muscle weakness exacerbated by repetitive use. Good's syndrome, an adult-onset immunodeficiency associated with thymomas, results in hypogammaglobulinemia and susceptibility to opportunistic infections, which can be life-threatening.
View Article and Find Full Text PDFAssociation between Infection and Calculated Globulin Level among Patients with Thymic Epithelial Tumor.
J Clin Med
September 2024
Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA.
: Thymic epithelial tumors (TETs) are uncommon malignancies uniquely associated with autoimmunity and immunodeficiency. Previous studies among patients with primary immunodeficiency diseases have shown that a low calculated globulin (CG) level, obtained by subtracting albumin from total protein level, is associated with infection risk. We investigated this association among patients with TET.
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