Administration of single IP doses of 1.0 or 4.0 mg/kg of d-amphetamine evoked an increase in mouse spontaneous motor activity (SMA); in contrast, 1.0 mg/kg of l-amphetamine had no significant effect, while 4.0 mg/kg caused a decreased SMA. Pretreatment with aMT or pargyline had little effect on the actions of the l-isomer, but reduced the magnitude and duration of the stimulatory effect of d-amphetamine. Pretreatment with p-chlorophenylalanine had little effect on the actions of d-amphetamine but completely abolished the depressant actions of the l-isomer. Reserpine pretreatment markedly reduced basal SMA levels; such pretreatment caused both d- and l-amphetamine to act as stimulants of SMA.
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http://dx.doi.org/10.1016/0091-3057(78)90081-3 | DOI Listing |
Int J Pharm
November 2024
Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China. Electronic address:
Over 90 % of chiral drugs applied in transdermal drug delivery system (TDDS) are racemates, significantly increasing risks of side effects. Herein, we designed a chiral molecularly imprinted patch (CMIP) that achieved enantioselectively controlled release of S-enantiomers (eutomers) and inhibited the release of R-enantiomers (distomers) for transdermal drug delivery. It is composed of chiral pressure sensitive adhesive (PSA) and molecularly imprinted polymers (MIP), showing better transdermal delivery of S-enantiomers than that of R-enantiomers in vitro (1.
View Article and Find Full Text PDFCancers (Basel)
April 2024
Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115 Berlin, Germany.
Glyceraldehyde (GA) is a three-carbon monosaccharide that can be present in cells as a by-product of fructose metabolism. Bruno Mendel and Otto Warburg showed that the application of GA to cancer cells inhibits glycolysis and their growth. However, the molecular mechanism by which this occurred was not clarified.
View Article and Find Full Text PDFPathogens
June 2023
Microbiology, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Molecules
April 2021
Department of Chemistry, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.
Amino acids have a wide range of biological activities, which usually rely on the stereoisomer presented. In this study, glycine and 21 common α-amino acids were investigated for their herbicidal property against Chinese amaranth ( L.) and barnyard grass ( (L.
View Article and Find Full Text PDFJ Pharmacol Sci
September 2019
Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:
Information is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with I inhibitor-induced labile repolarization process. We compared the proarrhythmic effects of d-sotalol with those of dl-sotalol using the chronic atrioventricular block dogs, since d- and l-isomers share a similar blocking action on I but β-blocking activity resides only in l-isomer. dl-Sotalol (3 mg/kg, p.
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