Myeloperoxidase released from stimulated neutrophils is able to produce hypochlorous and hypobromous acids. The composition of the reaction products of the interaction of hypohalous acid with double bonds of phosphatidylcholines was analysed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry using reagents enriched in 16O, 18O, 35Cl, 37Cl, 79Br, or 81Br. Two different types of products were assigned according to the mass spectra. First, chlorohydrins as well as bromohydrins were formed whereby the oxygen introduced was derived from water as shown by using H2 16O or H2 18O. In the second product a hydrogen atom was replaced by a halogen. This was clearly evidenced by different mass shifts using chlorine or bromine isotopes and the lack of any effects by oxygen isotopes. These results are consistent with the view that two principal possibilities of stabilisation of pi-complexes formed after binding of Cl(+) or Br(+) to the pi-system of the double bond exist.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chemphyslip.2003.12.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural and molecular insights of two unique enzymes involved in the biosynthesis of a natural halogenated nitrile.
FEBS J
December 2024
Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Article Synopsis
- * The newly reported biosynthetic pathway for the cyanobacterial neurotoxin, aetokthonotoxin, features two novel enzymes: AetF (a halogenase) and AetD (a nitril synthase).
- * Recent studies on the crystal structures of AetF and AetD reveal their unique architectures and mechanisms, crucial for understanding their functions and potential uses in biotechnology.
Exploring mammalian heme peroxidases: A comprehensive review on the structure and function of myeloperoxidase, lactoperoxidase, eosinophil peroxidase, thyroid peroxidase and peroxidasin.
Arch Biochem Biophys
November 2024
Department of Biotechnology, Sharda School of Engineering and Technology, Sharda University, P.C. 201310, Greater Noida, U.P., India. Electronic address:
Article Synopsis
- - The peroxidase family of enzymes, particularly mammalian heme peroxidases, are essential for oxidizing various organic and inorganic substances, and are characterized by a heme group important for their activity.
- - Key members of this family include Lactoperoxidase (LPO), Eosinophil peroxidase (EPO), Myeloperoxidase (MPO), Thyroid peroxidase (TPO), and Peroxidasin (PXDN), each serving distinct biological functions like antibacterial actions and thyroid hormone synthesis.
- - Despite their beneficial roles, dysfunctions in these enzymes are linked to diseases such as myocardial infarction, asthma, and Alzheimer’s, making their study critical for understanding both health and
Revisiting iodide species transformation in peracetic acid oxidation: unexpected role of radicals in micropollutants decontamination and iodate formation.
Water Res
November 2024
State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai,200092, China. Electronic address:
Peracetic acid (PAA) is an alternative disinfectant for saline wastewaters, and hypohalous acids are typically regarded as the reactive species for oxidation and disinfection. However, new results herein strongly suggest that reactive radicals instead of HOI primarily contributed to decontamination during PAA treatment of iodine-containing wastewater. The presence of I could greatly accelerate the micropollutants (e.
View Article and Find Full Text PDFImpact and pathway of halogens on atmospheric oxidants in coastal city clusters in the Yangtze River Delta region in China.
Atmos Pollut Res
February 2024
Center for Environmental Measurement & Modeling, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Halogens (chlorine, bromine, and iodine) are known to profoundly influence atmospheric oxidants (hydroxyl radical (OH), hydroperoxyl radical (HO), ozone (O), and nitrate radical (NO)) in the troposphere and subsequently affecting air quality. However, their impact on atmospheric oxidation and air pollution in coastal areas in China is poorly characterized. In this study, we use the WRF-CMAQ (Weather Research and Forecasting-Community Multiscale Air Quality) model with full halogen chemistry and process analysis to assess the influences and pathways of halogens on atmospheric oxidants in the Yangtze River Delta (YRD) region, a typical coastal city cluster in China.
View Article and Find Full Text PDFDefect Engineered BiTe Nanosheets with Enhanced Haloperoxidase Activity for Marine Antibiofouling.
Small
October 2024
Institute of Biophotonics, National Yang-Ming Chiao Tung University, 155, Sec-2 Li Nong Street, Taipei, 112, Taiwan.
Defective bismuth telluride (BiTe) nanosheets, an artificial nanozyme mimicking haloperoxidase activity (hPOD), show promise as eco-friendly, bactericidal, and antimicrofouling materials by enhancing cytotoxic hypohalous acid production from halides and HO. Microscopic and spectroscopic characterization reveals that controlled NaOH (upto X = 250 µL) etching of the nearly inactive non-transition metal chalcogenide BiTe nanosheets creates controlled defects (d), such as Bispecies, in d-BiTe-X that induces enhanced hPOD activity. d-BiTe-250 exhibits approximately eight-fold improved hPOD than the as-grown BiTe nanosheets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!