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Outcomes of neoadjuvant chemoradiotherapy in T4 rectal cancer patients: a real-world single institution experience.
Radiat Oncol J
December 2024
Department of Radiation Oncology, Cancer Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: Treatment outcomes of locally advanced rectal cancer have improved significantly in recent decades. This retrospective study aimed to assess the efficacy of neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with T4 rectal cancer and the different outcomes between T4a and T4b patients.
Materials And Methods: A total of 60 clinically T4 rectal cancer patients who underwent nCRT were included in the analysis.
Unlabelled: The evolution of axillary management in breast cancer has witnessed significant changes in recent decades, leading to an overall reduction in surgical interventions. There have been notable shifts in practice, aiming to minimize morbidity while maintaining oncologic outcomes and accurate staging for newly diagnosed breast cancer patients. These advancements have been facilitated by the improved efficacy of adjuvant therapies.
View Article and Find Full Text PDFComparison of neoadjuvant chemoimmunotherapy and neoadjuvant chemotherapy for resectable esophageal squamous cell carcinoma: a retrospective study with 3-year survival analysis.
J Cancer Res Clin Oncol
October 2024
Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Article Synopsis
- Neoadjuvant chemoimmunotherapy (nCIT) shows better short-term outcomes than neoadjuvant chemotherapy (nCT) for patients with locally advanced esophageal squamous cell cancer (ESCC), particularly in terms of pathological responses and survival rates.
- A study analyzed 131 pairs of patients treated with nCIT or nCT, finding that nCIT led to higher rates of complete tumor response and improved surgical outcomes, including tumor down-staging and lymph node clearance.
- Although nCIT resulted in better disease-free survival (DFS) and overall survival (OS) at 3 years, further research is required to confirm long-term benefits.
Clinical breast examination: A screening tool for lower- and middle-income countries.
Asia Pac J Clin Oncol
December 2024
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Breast cancer (BC) remains a global health challenge, devastatingly impacting women's lives. Low-and-middle-income countries (LMIC), such as India, experience a concerning upward trend in BC incidence, necessitating the implementation of cost-effective screening methods. While mammography, ultrasonography, and magnetic resonance imaging are preferred screening modalities in resource-rich settings, limited resources in LMICs make clinical breast examination (CBE) the method of choice.
View Article and Find Full Text PDFMucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma.
BMC Gastroenterol
August 2024
The First Affiliated Hospital, Institute of Oncology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Background: Neoadjuvant chemoradiotherapy (NCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer (LARC). Mucinous adenocarcinoma (MAC) is a potential poor prognosis subgroup of rectal cancer. However, the predictive value of MAC in NCRT treatment of LARC is controversial.
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