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KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE-mediated Activation.
Eur J Immunol
December 2024
Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Mast cell (MC)-driven allergic diseases are constantly expanding and require the development of novel pharmacological MC stabilizers. Allergen/antigen (Ag)-triggered activation via crosslinking of the high-affinity receptor for IgE (FcεRI) is fundamentally regulated by SRC family kinases, for example, LYN and FYN, exhibiting positive and negative functions. We report that KIRA6, an inhibitor for the endoplasmic reticulum stress sensor IRE1α, suppresses IgE-mediated MC activation by inhibiting both LYN and FYN.
View Article and Find Full Text PDFFactors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry.
Respir Med
January 2025
Ankara University School of Medicine, Department of Chest Disease, Division of Immunology and Allergy, Ankara, Turkey.
Current guidelines recommend adding long-acting muscarinic antagonists (LAMAs) in patients with uncontrolled asthma, despite the use of moderate to high doses of inhaled steroid-long-acting beta agonists (ICS/LABA). This study aims to analyze the factors related to the prescription of add-on LAMA in clinical practice for asthma patients, shedding light on physicians' preferences. This study included adult asthma patients on add-on LAMA and ICS/LABA monitored for at least one year in a national registry comprising 2053 asthmatics.
View Article and Find Full Text PDFAntibiotics in honey: a comprehensive review on occurrence and analytical methodologies.
Open Res Eur
November 2024
National Institute for Agricultural and Veterinary Research, Rua dos Lagidos, Lugar da Madalena, Vila do Conde, 4485-655, Portugal.
Honey is a food of great nutritional importance and has always been used for human consumption. The production of honey and other beekeeping products depends on the proper functioning of this extremely important sector, as it has a direct impact on other sectors such as agriculture. The decline in bee colony numbers has been linked, among other factors, to bacterial diseases affecting bees, including American and European foulbrood, and spp.
View Article and Find Full Text PDFSingle-Atom Catalysts with Isolated Cu-N Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling.
Small
December 2024
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Article Synopsis
- * A new single-atom catalyst, Cu-N ISAC, has been developed to mimic three types of antioxidant enzymes, effectively reducing harmful reactive oxygen species (ROS) and protecting skin cells from oxidative stress damage.
- * In experiments, Cu-N ISAC demonstrated better efficacy than the standard treatment, showing potential for reducing inflammation and enhancing PPAR signaling, which could help in treating AD and other related conditions.
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