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Castleman's Disease Presenting as an Unusual Pelvic Retroperitoneal Mass.
Cureus
October 2024
General Surgery, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Castleman's disease (CD) is characterised by benign lymphoepithelial proliferation and is a peculiar form of angiofollicular lymph node hyperplasia rather than a neoplasm or a hamartoma. CD is broadly classified as unicentric CD (UCD) and multicentric CD. In the unicentric variant, patients have localised disease affecting only a single lymph node or a group of adjacent nodes in a single region, which clinically presents as an enlarging mass without any other significant symptoms.
View Article and Find Full Text PDFConstrictive bronchiolitis and paraneoplastic pemphigus caused by unicentric Castleman disease in a young woman: a case report.
Front Med (Lausanne)
October 2024
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Constrictive bronchiolitis is a rare, severe condition causing irreversible small airway obstruction, potentially linked to an autoimmune syndrome stemming from Castleman disease.
- A 20-year-old female suffered from progressive breathing difficulties and oral sores, leading to an investigation that revealed a pelvic mass diagnosed as Castleman disease.
- Despite surgery to remove the mass alleviating some symptoms, she eventually required a lung transplant to significantly improve her lung function, highlighting the need for timely and thorough medical intervention.
Idiopathic multicentric Castleman disease.
J Cancer Res Ther
July 2024
Department of Medicine, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
Article Synopsis
- An elderly man experienced six months of fever, chills, weight loss, bilateral swelling, and non-tender lymph nodes, combined with findings of anemia and elevated inflammatory markers.
- Ultrasound and fine-needle aspiration revealed enlarged necrotic lymph nodes and no signs of tuberculosis, leading to further biopsies.
- The final diagnosis indicated plasma cell variant of multicentric Castleman disease, confirmed through histopathology after the patient underwent a bilateral orchidectomy due to concerns about testicular cancer.
Renal Neoplasms with Concurrent Castleman-Like Regional Lymphadenopathy.
Int J Surg Pathol
August 2024
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Introduction: Renal cell neoplasms are known to be associated with paraneoplastic syndromes, and the association with Castleman-like regional lymphadenopathy has been rarely reported. We aim to characterize the association between renal neoplasms and Castleman-like lymphadenopathy.
Methods: A search for renal neoplasms with concurrent Castleman-like lymphadenopathy in one single medical institution from 2000 to 2023 resulted in 4 specimens.
Abdominal CT findings characteristic of Castleman disease: multi-centre review of 76 adult cases with abdominopelvic nodal involvement.
Br J Radiol
August 2024
Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, Iowa 52242, United States.
Article Synopsis
- - The study aimed to identify CT scan characteristics of abdominopelvic Castleman disease, particularly focusing on a new finding related to the surrounding fat tissue (perinodal fat).
- - Researchers analyzed data from 76 adults with confirmed Castleman disease and evaluated factors like nodal mass size, enhancement patterns, and fat infiltration.
- - Results showed that a majority of cases had hypervascular nodal masses and fat infiltration, indicating that these features might help accurately diagnose Castleman disease, especially the hyaline vascular variant (HVV).
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