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Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content.
Sci Rep
October 2023
Cell Biology Unit, de Duve Institute and Louvain University Medical School, Brussels, Belgium.
Megalin/LRP2 is a major receptor supporting apical endocytosis in kidney proximal tubular cells. We have previously reported that kidney-specific perinatal ablation of the megalin gene in cystinotic mice, a model of nephropathic cystinosis, essentially blocks renal cystine accumulation and partially preserves kidney tissue integrity. Here, we examined whether inhibition of the megalin pathway in adult cystinotic mice by dietary supplementation (5x-fold vs control regular diet) with the dibasic amino-acids (dAAs), lysine or arginine, both of which are used to treat patients with other rare metabolic disorders, could also decrease renal cystine accumulation and protect cystinotic kidneys.
View Article and Find Full Text PDFMacrophage reprogramming by negatively charged membrane phospholipids controls infection.
FASEB J
February 2019
Department of Surgery, School of Medicine, University of California San Diego, La Jolla, California, USA; and.
Extracellular vesicles (ECVs) are heterogeneous membrane-enclosed structures containing proteins, nucleic acids, and lipids that participate in intercellular communication by transferring their contents to recipient cells. Although most of the attention has been directed at the biologic effect of proteins and microRNA, the contribution of phospholipids present in ECVs on cellular activation has not been extensively addressed. We investigated the biologic effect of phosphatidylserine (PS) and phosphatidylcholine (PC), 2 phospholipids highly abundant in ECVs.
View Article and Find Full Text PDFStructure-function relationships of protein-lipopeptide complexes and influence on immunogenicity.
Amino Acids
October 2017
Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC, 3000, Australia.
The lipopeptide, RPamCys, associates electrostatically with soluble protein antigens and significantly enhances their ability to induce protective humoral and cell-mediated responses. We demonstrate that antibody titers elicited by the antigen ovalbumin (OVA) associated with RPamCys are higher than those elicited by OVA in the presence of alum and comparable to those elicited by OVA formulated with complete Freund's adjuvant (CFA). The hierarchy of anti-OVA antibody avidities was CFA > RPamCys = alum.
View Article and Find Full Text PDFInvestigations of the mechanism of the "proline effect" in tandem mass spectrometry experiments: the "pipecolic acid effect".
J Am Soc Mass Spectrom
October 2014
Department of Chemistry, The College of William and Mary, Williamsburg, VA, 23187, USA.
The fragmentation behavior of a set of model peptides containing proline, its four-membered ring analog azetidine-2-carboxylic acid (Aze), its six-membered ring analog pipecolic acid (Pip), an acyclic secondary amine residue N-methyl-alanine (NMeA), and the D stereoisomers of Pro and Pip has been determined using collision-induced dissociation in ESI-tandem mass spectrometers. Experimental results for AAXAA, AVXLG, AAAXA, AGXGA, and AXPAA peptides are presented, where X represents Pro, Aze, Pip, or NMeA. Aze- and Pro-containing peptides fragment according to the well-established "proline effect" through selective cleavage of the amide bond N-terminal to the Aze/Pro residue to give yn (+) ions.
View Article and Find Full Text PDFAssessment of the effectiveness of nontransdermal energy patches on muscle endurance and power.
J Strength Cond Res
May 2008
Department of Health and Human Performance, School of Applied Health and Educational Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Claims of recently developed energy patches suggest that organic nanoscale biomolecular "antennas" produced by L and D-stereoisomers resonate at frequencies in unison with molecules in the cells inducing electron flow to assists in recruiting calcium ions, allowing greater muscle fiber recruitment during muscle contraction. The purpose of the study was to assess the efficacy of energy patches in the performance of selected muscle power and endurance measures. After a 5-minute warm-up and stretch, 41 college varsity football players (age, 20.
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