AI Article Synopsis
- The myo-inositol catabolism pathway in Bacillus subtilis is incomplete but is believed to convert myo-inositol into acetyl-CoA and dihydroxyacetone phosphate through a series of reactions.
- The iolABCDEFGHIJ operon is responsible for this catabolism, with IolG catalyzing the initial step by converting myo-inositol to 2-keto-myo-inositol (inosose).
- Research has identified iolE, which encodes inosose dehydratase, the enzyme that further processes inosose into D-2,3-diketo-4-deoxy-epi-inositol.
Article Abstract
The myo-inositol catabolism pathway of Bacillus subtilis has not been fully characterized but was proposed to involve step-wise multiple reactions that finally yielded acetyl-CoA and dihydroxyacetone phosphate. It is known that the iolABCDEFGHIJ operon is responsible for the catabolism of inositol. IolG catalyses the first step of myo-inositol catabolism, the dehydrogenation of myo-inositol, producing 2-keto-myo-inositol (inosose). The second step was thought to be the dehydration of inosose. Genetic and biochemical analyses of the iol genes led to the identification of iolE, encoding the enzyme for the second step of inositol catabolism, inosose dehydratase. The reaction product of inosose dehydratase was identified as D-2,3-diketo-4-deoxy-epi-inositol.
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| http://dx.doi.org/10.1099/mic.0.26768-0 | DOI Listing |
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