AI Article Synopsis
- Serum proteins differ significantly between sarcomatous and healthy soft shell clams, with sarcomatous clams having a higher total protein concentration.
- Unique serum proteins were identified in both sarcomatous (M(r)23,000, 45,000, 54,000) and healthy clams (M(r) 24,000, 103,000, 105,000), indicating distinct protein profiles.
- The presence of sarcoma-specific proteins during disease progression suggests they may promote tumors or have cytotoxic effects, while disappearing normal proteins could be linked to the immune defense system.
Article Abstract
1. Serum proteins showed quantitative and qualitative differences between sarcomatous and healthy soft shell clams, Mya arenaria L. 2. Total protein concentration was significantly higher in the serum of sarcomatous clams than of healthy clams. 3. According to SDS-PAGE, more serum proteins with more variability distinguished sarcomatous clams from healthy ones. 4. Sarcomatous clams had unique serum proteins of M(r)23,000, 45,000 and 54,000. Healthy clams had unique serum proteins of M(r) 24,000, 103,000 and 105,000. 5. During disease progression, sarcoma-specific proteins appeared while normal proteins disappeared. 6. We propose that some sarcoma-associated proteins may have tumor promoting and/or cytotoxic functions and that some normal proteins which disappear during disease progression may be involved in the humoral defense system.
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| http://dx.doi.org/10.1016/0305-0491(92)90057-x | DOI Listing |
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