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Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia's National Bowel Cancer Screening Programme.
Epidemiol Psychiatr Sci
December 2024
School of Public Health, Curtin University, Perth, Western Australia, Australia.
Aims: Studies show that people with severe mental illness (SMI) have a greater risk of dying from colorectal cancer (CRC). These studies mostly predate the introduction of national bowel cancer screening programmes (NBCSPs) and it is unknown if these have reduced disparity in CRC-related mortality for people with SMI.
Methods: We compared mortality rates following CRC diagnosis at colonoscopy between a nationally representative sample of people with and without SMI who participated in Australia's NBCSP.
Outpatient Management of Bipolar Disorder in Older Adults.
Curr Psychiatry Rep
December 2024
Department of Psychiatry and Behavioral Sciences, Dell Medical School, The University of Texas at Austin, AMG Seton Behavioral Health, 1301 W. 38th Street, Suite 700, Austin, TX, 78757, USA.
Article Synopsis
- Older adults with bipolar disorder (OABD) face unique challenges in diagnosis and treatment, particularly in outpatient settings.
- Mood episodes in OABD are similar in frequency and severity to those in younger adults, with depression being more common and mixed symptoms frequent.
- Effective treatment may involve using lower doses of lithium over other medications, and clinicians should focus on managing medical comorbidities and reducing the number of medications prescribed.
Lithium Enhances Ferroptosis sensitivity in melanoma cells and promotes CD8 T Cell infiltration and differentiation.
Free Radic Biol Med
February 2025
School of Biopharmacy, China Pharmaceutical University, Nanjing, 211198, China; Changzhou High-tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou, 213164, China; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210032, China; Faculty of Pharmaceutical Sciences, Xinxiang Medical University, Xinxiang, 453003, China. Electronic address:
Lithium exposure reduces melanoma incidence and mortality, yet its therapeutic mechanisms are unclear. This study explores the effects of lithium on ferroptosis sensitivity and anti-tumor T cell response in melanoma. We found that lithium significantly enhanced RSL3-induced ferroptosis in vitro, evidenced by increased mitochondrial peroxide, lipid peroxidation, and mitochondrial abnormalities.
View Article and Find Full Text PDFEfficacy of Low-Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats.
J Neurosci Res
November 2024
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second-line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium-pilocarpine in male Sprague-Dawley rats. Seventy-two male Sprague-Dawley rats were divided into nine groups.
View Article and Find Full Text PDFPre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients.
Clin Kidney J
November 2024
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Augustenburger Platz 1, Berlin, Germany.
Article Synopsis
- Hypernatremia is a common and serious condition in ICU patients, linked to higher mortality and longer stays, prompting this study to compare sodium chloride 0.9% and glucose 5% solutions as intravenous drug diluents.
- The study analyzed 265 adult COVID-19 patients, observing sodium levels and severe hypernatremia over the first 8 days after ICU admission, finding that glucose 5% led to lower sodium levels and reduced occurrences of severe hypernatremia.
- The results suggest that switching to glucose 5% as the standard diluent can help prevent hypernatremia in ICU patients, indicating a potentially simple change in treatment protocols.
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