Research suggests that when people are fear conditioned to masked spiders and snakes (electric shocks are contingent on only spiders or snakes), they acquire a conditional skin conductance response and can predict the occurrence of shocks even though they are unable to identify the masked spiders and snakes. Because in prior studies trial order was not completely random, it is unclear if findings were due to the contingencies from differential conditioning or a restricted trial order or both. When participants were assigned to four groups to disentangle effects of trial order and differential conditioning to masked pictures in acquisition, effects were obtained only for trial order. These findings demonstrate that trial order can result in conditioning. However, because effects were observed even for participants who reported unawareness of the contingency from trial order, results are consistent with the notion of hunches or gut feelings.
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http://dx.doi.org/10.1111/1469-8986.00117 | DOI Listing |
Clin Nutr ESPEN
January 2025
Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, Belgium. Electronic address:
Background And Aims: Alcohol Use Disorder (AUD) is a psychiatric disorder characterized notably by gut microbial dysbiosis and insufficient dietary fiber intake. This study aims to investigate the effect of dietary fiber placebo-controlled intervention in patients suffering from AUD during a three-week period of alcohol withdrawal, in order to discover microbial-derived metabolites that could be involved in metabolic and behavioral status.
Methods: A randomized, double-blind, placebo-controlled study was performed with 50 AUD patients supplemented with inulin (prebiotic dietary fiber) or maltodextrin (placebo) during 17 days.
Eur J Cancer
January 2025
Department of Dermatology, Côte d'Azur University, University Hospital Center of Nice, France.
Background: Radiotherapy is thought to enhance anti-tumor immunity, particularly when delivered in a hypofractionated and multisite manner. Therefore, we investigated the effects of combining radiotherapy with nivolumab in patients with advanced melanoma.
Methods: This was a multicenter, non-randomized, phase 2 trial that enrolled patients with treatment-naïve metastatic melanoma.
BMC Plant Biol
January 2025
Colorado Water Center, Colorado State University, Fort Collins, CO, USA.
Background: Incorporating organic manure improves soil properties and crop productivity. A long-term study started in October 1967 examined the effects of farmyard manure and nitrogen fertilization on the soil at key growth stages of pearl millet in a pearl millet-wheat cropping system over its 51st cycle.
Results: Applying 15 Mg of farmyard manure (FYM) per hectare in both growing seasons significantly boosted soil organic carbon (SOC), dissolved organic carbon (DOC), and key nutrients compared to one-season application.
BDJ Open
January 2025
Department of Orthodontics, Institute of Dentistry, Medical Faculty, Jagiellonian University, Kraków, Poland.
Background And Objectives: Gingivitis and periodontitis are common periodontal diseases that can significantly harm overall oral health, affecting the teeth and their supporting tissues, along with the surrounding anatomical structures, and if left untreated, leading to the total destruction of the alveolar bone and the connective tissues, tooth loss, and other more serious systemic health issues. Numerous studies have shown that propolis can help reduce gum inflammation, inhibit the growth of pathogenic bacteria, and promote tissue regeneration, but with varying degrees of success reported. For this reason, this comprehensive systematic review aims at finding out the truth concerning the efficacy of propolis mouthwashes in treating gingivitis and periodontitis, as its main objective.
View Article and Find Full Text PDFLancet Neurol
February 2025
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada; Department of Cognitive Neurology, St Joseph's Health Care London, London, ON, Canada. Electronic address:
Background: No treatments exist for apathy in people with frontotemporal dementia. Previously, in a randomised double-blind, placebo-controlled, dose-finding study, intranasal oxytocin administration in people with frontotemporal dementia improved apathy ratings on the Neuropsychiatric Inventory over 1 week and, in a randomised, double-blind, placebo-controlled, crossover study, a single dose of 72 IU oxytocin increased blood-oxygen-level-dependent signal in limbic brain regions. We aimed to determine whether longer treatment with oxytocin improves apathy in people with frontotemporal dementia.
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