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Cross-species single-nucleus analysis reveals the potential role of whole-genome duplication in the evolution of maize flower development.
BMC Genomics
January 2025
Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences in Weifang, Weifang, Shandong, 261325, China.
Background: The evolution and development of flowers are biologically essential and of broad interest. Maize and sorghum have similar morphologies and phylogeny while harboring different inflorescence architecture. The difference in flower architecture between these two species is likely due to spatiotemporal gene expression regulation, and they are a good model for researching the evolution of flower development.
View Article and Find Full Text PDFA Smart Semi-Implantable Device Integrating Microchannel-Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification.
Adv Sci (Weinh)
December 2024
Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Monitoring deep wounds is challenging but necessary for high-quality medical treatment. Current methodologies for deep wound monitoring are typically limited to indirect clinical symptoms or costly non-real-time imaging diagnosis. Herein, a smart system is proposed that enables in situ monitoring of deep wounds' status through a semi-implantable device composed of 2 seamlessly connected functional components: 1) the well-designed, microchannel-structured sampling needles that efficiently and conveniently collect samples from deep wound anatomical locations, and 2) the multiplex biochemical testing compartment that facilitates the immediate and persistent detection of multiple biochemical indicators based on a color image processing software accessible to a conventional smartphone.
View Article and Find Full Text PDFThe CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.
Proc Natl Acad Sci U S A
January 2025
Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Department of Biochemistry and Molecular Biology, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, China.
Poly(ADP-ribose) polymerase 1 (PARP1) plays a crucial role in DNA repair and genomic stability maintenance. However, the regulatory mechanisms governing PARP1 activity, particularly through deubiquitination, remain poorly elucidated. Using a deubiquitinase (DUB) library binding screen, we identified cylindromatosis (CYLD) as a bona fide DUB for PARP1 in breast cancer cells.
View Article and Find Full Text PDFComprehensive Transcriptomic and Physiological Insights into the Response of Root Growth Dynamics During the Germination of Diverse Sesame Varieties to Heat Stress.
Curr Issues Mol Biol
November 2024
Institute of Chinese Herbal Medicines, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Heat stress constitutes a serious threat to sesame ( L.). Root development during seed germination plays an essential role in plant growth and development.
View Article and Find Full Text PDFAn Interior/Exterior Collaboration-Enhanced Intestinal Anastomosis (IECIA) for Multi-Tiered Leakage Complication Management.
Small
December 2024
Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Article Synopsis
- Anastomotic leakage (AL) is a serious postoperative issue that is hard to prevent and diagnose, leading to high rates of illness and death.
- A new method called interior/exterior collaboration-enhanced intestinal anastomosis (IECIA) uses a hydrogel barrier on the inside and an external protective safeguard to significantly reduce the risk of leakage.
- This system has shown promising results in studies, offering better recovery for gastrointestinal functions and being biocompatible and easy to use in surgical operations, making it a valuable option for clinical application.
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