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Risk Factors and Outcomes of Mucorales Infection in a Modern Cohort of Solid Organ Transplant, Hematopoietic Cell Transplant, and Chimeric Antigen Receptor T-cell Therapy Recipients.
Transplant Proc
September 2024
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
Article Synopsis
- Mucorales infections lead to high morbidity and mortality rates in immunocompromised patients, such as those receiving solid organ or hematopoietic cell transplants, despite advances in diagnosis and treatment.!* -
- A study analyzed 43 patients with Mucorales infections, finding that most developed the infection around 184 days post-transplant, with a 64% overall mortality rate; fatalities were mainly linked to Mucormycosis and common in disseminated disease.!* -
- The findings highlight a gap in effective prophylaxis and treatment strategies, indicating that improved data post-transplant can aid in managing Mucormycosis and emphasizing the need for further research on antifungal treatments.!
Mucorales: A systematic review to inform the World Health Organization priority list of fungal pathogens.
Med Mycol
June 2024
Infectious Diseases Institute (Sydney ID), The University of Sydney, Camperdown, New South Wales, Australia.
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list (FPPL). This systematic review aimed to evaluate the epidemiology and impact of invasive fungal disease due to Mucorales. PubMed and Web of Science were searched to identify studies published between January 1, 2011 and February 23, 2021.
View Article and Find Full Text PDFReal-World Experience with Isavuconazole in Allogeneic Stem Cell Transplantation in Spain.
Transplant Cell Ther
October 2024
Department of Hematology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Invasive fungal infections (IFI) pose a significant complication after hematopoietic stem cell transplantation (HSCT). Isavuconazole (ISV) is a new generation azole with a favourable adverse effect and interaction profile approved for the treatment of invasive aspergillosis and mucormycosis. We analyzed the indications, effectiveness, adverse event profile and drug interaction management of ISV in the real-world setting in adults who received allogeneic-HSCT (allo-HSCT) within the Spanish Group of HSCT and Cell Therapy (GETH-TC).
View Article and Find Full Text PDFFrom Spores to Solutions: A Comprehensive Narrative Review on Mucormycosis.
Diagnostics (Basel)
January 2024
Department of Microbiology, Government Medical College and Hospital, Chandigarh 160030, India.
Mucormycosis is an infrequent but fatal illness that mainly affects patients with uncontrolled diabetes mellitus, diabetic ketoacidosis, solid and hematologic neoplasms, organ transplantation, chronic steroid intake, prolonged neutropenia, iron overload states, neonatal prematurity, severe malnutrition, and HIV. Many cases were reported across the world recently following the COVID-19 pandemic. Recent research has led to a better understanding of the pathogenesis of the disease, and global guidelines are now available for managing this serious infection.
View Article and Find Full Text PDFAn unusual opportunistic infection causing lower gastrointestinal tract bleeding in a patient with severe alcoholic hepatitis, post-liver transplantation.
Transpl Infect Dis
August 2023
Department of Gastroenterology and Hepatology, PACE Hospitals, Hyderabad, Telangana, India.
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