Drugs mistakenly administered into the epidural space can have serious neurologic sequelae. This case reports the inadvertent administration of ephedrine during labor in a 17-year-old woman. The possible complications for both the mother and fetus are discussed and compared with other published literature reports.
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http://dx.doi.org/10.1016/j.jclinane.2003.07.001 | DOI Listing |
Eur J Pharmacol
February 2025
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan; Department of Pharmacy, Korea University, Sejong, 20019, South Korea. Electronic address:
The study investigated the anxiolytic, antidepressant, sedative/hypnotic and in silico molecular docking properties of the synthetic ephedrine-based derivative of thiourea, 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea. Safety profile of the compound at various doses was determined in an acute toxicity test. Results showed significant anti-anxiety effects of the compound in all mice studies.
View Article and Find Full Text PDFCureus
November 2024
Neuroanesthesia, Unidade Local de Saúde de Santo António, Porto, PRT.
Cureus
October 2024
Anaesthesiology, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University), Pune, IND.
Background: In parturients, post-spinal hypotension is common due to loss of sympathetic tone. Compression of the inferior vena cava by the gravid uterus further aggravates it. Various pharmacologic and non-pharmacologic techniques are used to reduce the severity of hypotension.
View Article and Find Full Text PDFHeliyon
November 2024
Healthcare Sensing Technology, Faculty Research Centre for Intelligent Healthcare, Coventry University, Coventry, United Kingdom.
Cureus
October 2024
General Surgery, Northwell Health Staten Island University Hospital, New York, USA.
Although rare, local anesthetic use has been associated with adverse central nervous system and cardiovascular adverse events. One complication is local anesthetic systemic toxicity (LAST), wherein the anesthetic agent inadvertently enters systemic circulation resulting in widespread inhibition of fast-gated sodium channels. Organs dependent on aerobic metabolism, such as the heart and brain, are especially susceptible to toxic injury resulting in cardiovascular collapse.
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