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EPR Characterization of the BlsE Substrate Radical Offers Insight into the Determinants of Reaction Outcome that Distinguish Radical SAM Dioldehydratases from Dehydrogenases.
J Am Chem Soc
January 2025
Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
A small but growing set of radical SAM (-adenosyl-l-methionine) enzymes catalyze the radical mediated dehydration or dehydrogenation of 1,2-diol substrates. In some cases, these activities can be interchanged via minor structural perturbations to the reacting components raising questions regarding the relative importance of hyperconjugation, proton circulation and leaving group stability in determining the reaction outcome. The present work describes trapping and electron paramagnetic resonance (EPR) characterization of an α-hydroxyalkyl radical intermediate during dehydration and dehydrogenation of cytosylglucuronic acid and its derivatives catalyzed by the radical SAM enzyme BlsE and its Glu189Ala mutant from the blasticidin S biosynthetic pathway.
View Article and Find Full Text PDFConfinement Induces Morphological and Topological Transitions in Multivesicles.
ACS Nano
January 2025
Instituto de Histología y Embriología de Mendoza (IHEM)─Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCuyo), 5500 Mendoza, Argentina.
The study of self-assembly in confined spaces has gained significant attention among amphiphilic superstructures and colloidal design. The additional complexity introduced by interactions between contents and their containers, along with the effects of shape and lipid mixing, makes multivesicular bodies an interesting subject of study. Despite its promising applications in biomedicine, such as drug delivery and biomimetic materials, much remains unexplored.
View Article and Find Full Text PDFPrecisely Designed Hydrophilic Networks in Microporous Layer for High Performance of Proton Exchange Membrane Fuel Cells.
ACS Appl Mater Interfaces
January 2025
School of Automotive Studies, Tongji University, Shanghai 201804, China.
Proton exchange membrane fuel cell (PEMFC) is considered the next promising generation of power devices for vehicles. The microporous layer (MPL) improves the performance through effective water management. In this study, local hydrophilic networks of nano- and macropores are formed in different MPLs.
View Article and Find Full Text PDFApplication of spray-dried bacteriocins as cheese biopreservatives.
Int J Food Microbiol
January 2025
Instituto de Investigaciones para la Industria Química, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Salta (INIQUI-CONICET-UNSa), Av. Bolivia 5150, A4408FVY Salta, Argentina; Facultad Ciencias de la Salud, Universidad Nacional de Salta (UNSa), Av. Bolivia 5150, A4408FVY Salta, Argentina. Electronic address:
Listeria monocytogenes can contaminate refrigerated ready-to-eat foods, such as cheeses. Enterocins, with a strong listericidal effect, constitute a natural alternative to control this pathogen in food. To optimize their antimicrobial action in food matrices, bacteriocins can be immobilised in edible coatings through spray drying technology which allows the large-scale production of microcapsules of bioactive molecules.
View Article and Find Full Text PDFObservational study: effect of varying transport durations and feed withdrawal on the physiological status and health of dairy calves.
Ir Vet J
January 2025
Department of Biological and Pharmaceutical Sciences, Munster Technological University Kerry, Tralee, V92 CX88, Ireland.
Long-distance transport and associated fasting of unweaned calves have the potential to compromise the animals' welfare. This observational study aimed to determine how transport and fasting durations impacted the physiology and health of 115 transported calves in three transport groups; IRE (n = 20, mean age 29.8d; short road transport (~ 29 h incl.
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