AI Article Synopsis
- The study assessed the effectiveness of moxifloxacin, both alone and with cefepime or piperacillin-tazobactam, against clinical strains of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii using time-kill assays.
- Synergistic effects were found in 58 to 88% of the bacterial strains tested, leading to complete bactericidal action in 60 to 100% of cases.
- When used in combination with moxifloxacin, the other antibiotics showed improved killing ability compared to using any of the agents by themselves.
Article Abstract
The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC353069 | PMC |
| http://dx.doi.org/10.1128/AAC.48.3.1055-1057.2004 | DOI Listing |
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