Small molecule N/OFQ receptor antagonists were designed and synthesized to further investigate the therapeutic potential of N/OFQ receptor modulators. The resulting octahydrobenzimidazol-2-ones 14 and 23 show excellent antagonistic activity towards both N/OFQ and mu receptors with high affinity to the human N/OFQ receptor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2003.11.083 | DOI Listing |
Publication Analysis
Top Keywords
n/ofq receptor
16
small molecule
8
molecule n/ofq
8
receptor antagonists
8
n/ofq
5
design synthesis
4
synthesis novel
4
novel small
4
receptor
4
antagonists small
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!